Evidence map›Paper›PMID 24485875›Full record

Trial reportThe Journal of surgical research2014

Impact of single immunosuppressive drug withdrawal on lymphocyte immunoreactivity.

Meenakshi Verma, Linda Awdishu, James Lane, Ken Park, Bayda Bahur, Wint Lwin, Halvor McGee, Robert Steiner, Patricia Finn, David Perkins

Open access · bronzeAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of surgical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Meenakshi VermaPulmonary and Critical Care Division, Department of Medicine, University of California, San Diego, California.
Linda AwdishuSan Diego Health System, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California.
James LaneSan Diego Health System, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California.
Ken ParkPulmonary and Critical Care Division, Department of Medicine, University of California, San Diego, California.
Bayda BahurPulmonary and Critical Care Division, Department of Medicine, University of California, San Diego, California.
Wint LwinPulmonary and Critical Care Division, Department of Medicine, University of California, San Diego, California.
Halvor McGeePulmonary and Critical Care Division, Department of Medicine, University of California, San Diego, California; Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Robert SteinerSan Diego Health System, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California.
Patricia FinnPulmonary and Critical Care Division, Department of Medicine, University of California, San Diego, California; Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
David PerkinsPulmonary and Critical Care Division, Department of Medicine, University of California, San Diego, California; Department of Surgery, University of Illinois at Chicago, Chicago, Illinois. Electronic address: perkinsd@uic.edu.
University of California, San Diego · USUniversity of California System · USUniversity of Illinois Chicago · US

Funding

Transplantation: Alloimmune NetworksR01AI075317 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FINN, PATRICIA W, PERKINS, DAVID LINN · 2009 to 2011
$803k
NIAID NIH HHS R01 AI075317
6 · The paper itself

Abstract

backgroundChronic rejection is a major cause of graft loss in kidney transplant recipients. Nonadherence to drug therapy is a well-recognized cause of chronic rejection leading to long-term graft dysfunction and failure for transplant recipients. Immunosuppressive medications with short half-lives that require frequent dosing, such as tacrolimus, complicate transplant regimens and may increase noncompliance. Regimens could be simplified using drugs with long half-lives requiring once-daily administration, such as sirolimus. The impact of missing doses of single agents has not been studied extensively. Erratic compliance or temporary discontinuation of immunosuppressive drugs may have significant implications for chronic rejection.

methodsOur study evaluated the impact of single drug withdrawal of commonly used immunosuppressive agents (sirolimus and tacrolimus) on lymphocyte responses. We analyzed lymphocyte proliferation, cytokine secretion, and adenosine triphosphate generation using a crossover study design with normal healthy patients. Lymphocyte proliferation was assessed using 5-bromo-2-deoxyuridine incorporation, and T cell function was analyzed by examining adenosine triphosphate generation.

resultsOur results indicate that sirolimus exerts prolonged suppression of lymphocyte proliferation and decreased interleukin 17A that lasts up to 48 h after drug withdrawal. In comparison, tacrolimus did not have a similar effect on lymphocyte proliferation or interleukin 17A secretion.

conclusionFuture analysis of sirolimus in diverse transplantation populations merits investigation.

Indexed as

AdultCross-Over StudiesFemaleHealthy VolunteersHumansImmunosuppressive AgentsInterleukin-17LymphocytesMaleMiddle AgedSirolimusTacrolimusYoung AdultIL17A protein, humanImmunosuppressive AgentsInterleukin-17SirolimusTacrolimusImmunosuppressionRejectionSirolimusTacrolimusTransplantation

Identifiers

PMID24485875
PMCPMC7469978
OpenAlexW1989975964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.