ArticleDevelopmental biology2014
Epigenetic regulation of oogenesis and germ stem cell maintenance by the Drosophila histone methyltransferase Eggless/dSetDB1.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- The Many Faces of SetDB1.Epigenomes · 2026Review
- Evolutionary Dynamics of Transposable Element Activity and Regulation in the Apennine Yellow-Bellied Toad (Bombina pachypus).Genome biology and evolution · 2025Article
- piRNA Defense Against Endogenous Retroviruses.Viruses · 2024Review
- Inheritance of H3K9 methylation regulates genome architecture in Drosophila early embryos.The EMBO journal · 2024Article
- Genome organization regulates nuclear pore complex formation and promotes differentiation duringGenes & development · 2024Article
- The Ancient Origin and Function of Germline Cysts.Results and problems in cell differentiation · 2024Article
- SetDB1 and Su(var)3-9 are essential for late stages of larval development of Drosophila melanogaster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- A feedback loop between heterochromatin and the nucleopore complex controls germ-cell-to-oocyte transition during Drosophila oogenesis.Developmental cell · 2023Article
- Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis.bioRxiv : the preprint server for biology · 2023Article
- Article
- Single-cell RNA sequencing identifies eggplant as a regulator of germ cell development in Drosophila.EMBO reports · 2023Article
- The histone demethylase Kdm3 prevents auto-immune piRNAs production inScience advances · 2023Article
- Epigenetic regulation of drosophila germline stem cell maintenance and differentiation.Developmental biology · 2021Review
- Epigenetic regulation of post-embryonic development.Current opinion in insect science · 2021Review
- Genome organization: Tag it, move it, place it.Current opinion in cell biology · 2021Review
- Dlp-mediated Hh and Wnt signaling interdependence is critical in the niche for germline stem cell progeny differentiation.Science advances · 2020Article
- Mining histone methyltransferases and demethylases from whole genome sequence.Journal of biosciences · 2020Article
- Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing.EMBO reports · 2019Article
- A nuclear licence to silence transposons.EMBO reports · 2019Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila melanogaster histone lysine methyltransferase (HKMT) Eggless (Egg/dSETDB1) catalyzes methylation of Histone H3 lysine 9 (H3K9), a signature of repressive heterochromatin. Our previous studies showed that H3K9 methylation by Egg is required for oogenesis. Here we analyze a set of EMS-induced mutations in the egg gene, identify the molecular lesions of these mutations, and compare the effects on oogenesis of both strong loss-of-function and weak hypomorphic alleles. These studies show that H3K9 methylation by Egg is required for multiple stages of oogenesis. Mosaic expression experiments show that the egg gene is not required intrinsically in the germ cells for their early differentiation, but is required in the germ cells for their survival past stage 5 of oogenesis. egg is also required in germ stem cells for their maintenance, since egg- germ stem cells initially survive but are not maintained as females age. Mosaic analysis also reveals that the early egg chamber budding defects in egg- ovaries are due to an intrinsic requirement for egg in follicle stem cells and their descendents, and that egg plays a non-autonomous role in somatic cells in the germarium to influence the differentiation of early germ cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.