Evidence map›Paper›PMID 24485819›Full record

ArticleThe Journal of pediatrics2014

Longitudinal tracking of dual-energy X-ray absorptiometry bone measures over 6 years in children and adolescents: persistence of low bone mass to maturity.

Tishya A L Wren, Heidi J Kalkwarf, Babette S Zemel, Joan M Lappe, Sharon Oberfield, John A Shepherd, Karen K Winer, Vicente Gilsanz, Bone Mineral Density in Childhood Study Group

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Pooled it
  4. Trial
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  6. Pediatric Bone Mineral Accrual Z-Score Calculation Equations and Their Application in Childhood Disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Trial
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  19. The microbiome: A heritable contributor to bone morphology?Seminars in cell & developmental biology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Tishya A L WrenChildren's Hospital Los Angeles, Los Angeles, CA. Electronic address: twren@chla.usc.edu.
Heidi J KalkwarfCincinnati Children's Hospital Medical Center, Cincinnati, OH.
Babette S ZemelChildren's Hospital of Philadelphia, Philadelphia, PA.
Joan M LappeCreighton University, Omaha, NE.
Sharon OberfieldColumbia University, New York, NY.
John A ShepherdUniversity of California, San Francisco, San Francisco, CA.
Karen K WinerNational Institute of Child Health and Human Development, Bethesda, MD.
Vicente GilsanzChildren's Hospital Los Angeles, Los Angeles, CA.
Bone Mineral Density in Childhood Study Group

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR026314 · NCRR · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2009 to 2011
$14.3M
BONE MINERAL DENSITY IN CHILDHOOD STUDY--CLINICAL CENTER-275013330-275013330N01HD013330 · NICHD · CREIGHTON UNIVERSITY · PI LAPPE, JOAN · 2002 to 2006
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BONE MINERAL DENSITY IN CHILDHOOD STUDY--CLINICAL CENTER-275013331-275013331N01HD013331 · NICHD · CHILDREN'S HOSP. PHILADELPHIA · PI ZEMEL, BABETTE S · 2002 to 2006
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BONE MINERAL DENSITY IN CHILDHOOD STUDY-275013328-275013328N01HD013328 · NICHD · CLINICAL TRIALS &SURVEYS CORP · PI FREDERICK, MARGARET M · 2002 to 2006
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BONE MINERAL DENSITY IN CHILDHOOD STUDY--CLINICAL CENTER-275013333-275013333N01HD013333 · NICHD · CHILDRENS HOSPITAL LOS ANGELES · PI GILSANZ, VICENTE · 2002 to 2006
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BONE MINERAL DENSITY IN CHILDHOOD STUDY-CLINICAL CENTER-275013332-275013332N01HD013332 · NICHD · COLUMBIA UNIV. NEW YORK · PI HORLICK, MARY · 2002 to 2006
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BONE MINERAL DENSITY IN CHILDHOOD STUDY-CLINICAL CENTER-275013329-275013329N01HD013329 · NICHD · CHILDREN'S HOSP. MED CTR · PI KALKWARF, HEIDI J · 2002 to 2006
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NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR026314NICHD NIH HHS N01 HD013328NICHD NIH HHS N01 HD013329NICHD NIH HHS N01 HD013330NICHD NIH HHS N01 HD013331NICHD NIH HHS N01 HD013332NICHD NIH HHS N01 HD013333NICHD NIH HHS N01-HD-1-3228NICHD NIH HHS N01-HD-1-3329NICHD NIH HHS N01-HD-1-3330NICHD NIH HHS N01-HD-1-3331NICHD NIH HHS N01-HD-1-3332NICHD NIH HHS N01-HD-1-3333
6 · The paper itself

Abstract

objectivesEarly assessment of bone mass may be useful for predicting future osteoporosis risk if bone measures "track" during growth. This prospective longitudinal multicenter study examined tracking of bone measures in children and adolescents over 6 years to sexual and skeletal maturity. STUDY

designA total of 240 healthy male and 293 healthy female patients, ages 6-17 years, underwent yearly evaluations of height, weight, body mass index, skeletal age, Tanner stage, and dual-energy x-ray absorptiometry (DXA) bone measurements of the whole body, spine, hip, and forearm for 6 years. All subjects were sexually and skeletally mature at final follow-up. Correlation was performed between baseline and 6-year follow-up measures, and change in DXA Z-scores was examined for subjects who had baseline Z < -1.5.

resultsDXA Z-scores (r = 0.66-0.87) had similar tracking to anthropometric measures (r = 0.64-0.74). Tracking was stronger for bone mineral density compared with bone mineral content and for girls compared with boys. Tracking was weakest during mid- to late puberty but improved when Z-scores were adjusted for height. Almost all subjects with baseline Z < -1.5 had final Z-scores below average, with the majority remaining less than -1.0.

conclusionsBone status during childhood is a strong predictor of bone status in young adulthood, when peak bone mass is achieved. This suggests that bone mass measurements in children and adolescents may be useful for early identification of individuals at risk for osteoporosis later in life.

Indexed as

Absorptiometry, PhotonAnthropometryAdolescentAge FactorsBody HeightBody WeightBone DensityChildChild DevelopmentFemaleHealthy VolunteersHumansLongitudinal StudiesMaleOsteoporosisPredictive Value of Tests

Identifiers

PMID24485819
PMCPMC4035430

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.