ArticleCell reports2014
Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 135 citations in OpenAlex.
- Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration.Nature physics · 2026Article
- Article
- Lnc007185570.1-pal-miR-3120-3p-Biology · 2026Article
- Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration.iScience · 2026Article
- Actinotrichia-independent developmental mechanisms of spiny rays facilitate the morphological diversification of Acanthomorpha fish fins.Nature communications · 2026Article
- Voltage-gated calcium channels generate blastema Ca2+ fluxes restraining zebrafish fin regenerative outgrowth.Development (Cambridge, England) · 2025Article
- Sonic hedgehog signaling promotes basal epidermalbioRxiv : the preprint server for biology · 2025Article
- Ginsenoside Re promotes osteogenic differentiation via BMP2/p38 pathwayJournal of ginseng research · 2025Article
- Inhibition of Fin Regeneration in Fathead Minnow (Environmental science & technology · 2025Article
- Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Lack of Nuclear Localization of the Creb3l1 Transcription Factor Causes Defects in Caudal Fin Bifurcation in Zebrafish Danio rerio.Cells, tissues, organs · 2025Article
- The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases.Biomarker research · 2024Review
- Disruption of the creb3l1 gene causes defects in caudal fin regeneration and patterning in zebrafish Danio rerio.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Regeneration of the caudal fin of the evolutionary ancient tropical gar Atractosteus tropicus.BMC zoology · 2024Article
- The Regulatory Role of miRNAs in Zebrafish Fin Regeneration.International journal of molecular sciences · 2024Article
- Review
- A screen for regeneration-associated silencer regulatory elements in zebrafish.Developmental cell · 2024Article
- Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin.iScience · 2024Article
- Section Immunostaining for Protein Expression and Cell Proliferation Studies of Regenerating Fins.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Insulin-like growth factor receptor / mTOR signaling elevates global translation to accelerate zebrafish fin regenerative outgrowth.Developmental biology · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Zebrafish fully regenerate lost bone, including after fin amputation, through a process mediated by dedifferentiated, lineage-restricted osteoblasts. Mechanisms controlling the osteoblast regenerative program from its initiation through reossification are poorly understood. We show that fin amputation induces a Wnt/β-catenin-dependent epithelial to mesenchymal transformation (EMT) of osteoblasts in order to generate proliferative Runx2(+) preosteoblasts. Localized Wnt/β-catenin signaling maintains this progenitor population toward the distal tip of the regenerative blastema. As they become proximally displaced, preosteoblasts upregulate sp7 and subsequently mature into re-epithelialized Runx2(-)/sp7(+) osteoblasts that extend preexisting bone. Autocrine bone morphogenetic protein (BMP) signaling promotes osteoblast differentiation by activating sp7 expression and counters Wnt by inducing Dickkopf-related Wnt antagonists. As such, opposing activities of Wnt and BMP coordinate the simultaneous demand for growth and differentiation during bone regeneration. This hierarchical signaling network model provides a conceptual framework for understanding innate bone repair and regeneration mechanisms and rationally designing regenerative therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.