Evidence map›Paper›PMID 24485566›Full record

ArticleOral oncology2014

Human papillomavirus (HPV) status of non-tobacco related squamous cell carcinomas of the lateral tongue.

J S Poling, X-J Ma, S Bui, Y Luo, R Li, W M Koch, W H Westra

Abstract read
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In one paragraph

Article in Oral oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014
    Trial
  5. Article
  6. Trends in Oral Tongue Cancer Incidence in the US.JAMA otolaryngology-- head & neck surgery · 2024
    Article
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  8. Review
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  12. Review
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  14. Article
  15. Article
  16. Article
  17. The Role of Age and Merkel Cell Polyomavirus in Oral Cavity Cancers.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2020
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J S PolingDepartments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
X-J MaAdvanced Cell Diagnostics, Hayward, CA, USA.
S BuiAdvanced Cell Diagnostics, Hayward, CA, USA.
Y LuoAdvanced Cell Diagnostics, Hayward, CA, USA.
R LiOtolaryngology/Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
W M KochOtolaryngology/Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
W H WestraDepartments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Otolaryngology/Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address: wwestra@jhmi.edu.

Funding

TUMOR SUPPRESOR GENE PROMOTER HYPERMETHYLATION FOR DETECTION OF HEAD AND NECKP50DE019032 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI SIDRANSKY, DAVID · 2007 to 2016
$27.1M
NIDCR NIH HHS P50 DE019032
6 · The paper itself

Abstract

objectivesThe human papillomavirus (HPV) is an important cause of some head and neck squamous cell carcinomas (HNSCCs), but its role in cancer of the lateral tongue is debatable. Suspicion of HPV causation is heightened when these lateral tongue carcinomas arise in patients that are young and/or have never smoked. The purpose of this study was to determine the incidence of transcriptionally active high risk HPV in these tumors, with a particular emphasis on non-smoking patients who are often presumed to have HPV-positive tumors.

methodsWe evaluated 78 HNSCCs of the lateral tongue for the presence of HPV using p16 immunohistochemistry and an RNA in situ hybridization assay targeting HPV E6/E7 mRNA. The study population was enriched for patients without traditional risk factors such as smoking and drinking.

resultsP16 overexpression was detected in 9 (11.5%) of 78 cases, but HPV E6/E7 mRNA transcripts were detected in only 1 (1.3%) case (positive predictive value of p16 staining for the presence of transcriptionally active HPV=0.12). HPV mRNA transcripts were not detected in any patient under 40 (n=11), or in patients who had never smoked (n=44), had quit smoking (n=15), and/or were only light consumers of alcohol (n=57).

conclusionsHPV is not detected in the vast majority of lateral tongue carcinomas. In light of the observation that HPV plays little if any role in the development of these cancers, routine HPV testing is unwarranted , even for patients without traditional risk factors. P16 staining is not a reliable marker for the presence of transcriptionally active HPV at this particular anatomic site.

Indexed as

AdultCarcinoma, Squamous CellFemaleHumansMalePapillomaviridaeRNA, MessengerTongue NeoplasmsRNA, MessengerHead and neck cancerOral cancerP16RNA in situ hybridizationSmokingTobacco

Identifiers

PMID24485566
PMCPMC3972491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.