Evidence map›Paper›PMID 24485508›Full record

ArticleNeurobiology of aging2014

Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.

Sung Hoon Baik, Moon-Yong Cha, Young-Min Hyun, Hansang Cho, Bashar Hamza, Dong Kyu Kim, Sun-Ho Han, Heesun Choi, Kyung Ho Kim, Minho Moon and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. International journal of molecular sciences · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Neutrophil-to-Lymphocyte Ratio in the Alzheimer's Disease Continuum.International journal of molecular sciences · 2025
    Review
  19. Review
  20. Neuroinflammation in Alzheimer disease.Nature reviews. Immunology · 2025
    Review

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sung Hoon BaikDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Moon-Yong ChaDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Young-Min HyunDepartment of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
Hansang ChoBioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Bashar HamzaBioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Dong Kyu KimDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Sun-Ho HanDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Heesun ChoiDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Kyung Ho KimDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Minho MoonDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Jeewoo LeeDepartment of Pharmacology, College of Pharmacy, Seoul National University, Seoul, Korea.
Minsoo KimDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea; Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
Daniel IrimiaBioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Inhee Mook-JungDepartment of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea. Electronic address: inhee@snu.ac.kr.

Funding

Bio-MicroElectroMechanical Systems Resource CenterP41EB002503 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET · 2004 to 2018
$17.4M
Interdepartmental Neuroscience CenterP30NS045776 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, TANNOUS, BAKHOS A · 2003 to 2018
$11.1M
Neutrophil Decision Making in Confined Environments in Health and DiseaseR01GM092804 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI IRIMIA, DANIEL · 2010 to 2022
$4.3M
NIBIB NIH HHS P41 EB002503NIGMS NIH HHS R01 GM092804NINDS NIH HHS P30 NS045776
6 · The paper itself

Abstract

Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.

Indexed as

Alzheimer DiseaseAnimalsBrainCell MovementCells, CulturedDisease Models, AnimalHumansMiceMice, TransgenicMicroscopyMolecular ImagingNeutrophilsPlaque, AmyloidAlzheimer's diseaseAmyloid plaquesImmune cellsNeutrophils

Identifiers

PMID24485508
PMCPMC4248665

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.