Evidence map›Paper›PMID 24485448›Full record

ArticleCell2014

Mom's milk molds neural wiring for metabolism.

Isin Cakir, Umut Ozcan

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Isin CakirDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Umut OzcanDivision of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: umut.ozcan@childrens.harvard.edu.

Funding

Endoplasmic Reticulum Stress, Brain and ObesityR01DK098496 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI OZCAN, UMUT · 2013 to 2022
$4.6M
The In Vivo Role of JNK-1 and IRS-1 Ser307 Phosphorylation In Development of InsuR01DK081009 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI OZCAN, UMUT · 2008 to 2012
$1.7M
NIDDK NIH HHS R01DK081009NIDDK NIH HHS R01 DK098496NIDDK NIH HHS R01DK098496
6 · The paper itself

Abstract

Vogt et al. demonstrate that, in mice, maternal high-fat feeding during lactation is sufficient to program the offspring for impaired energy and glucose homeostasis throughout their lifetime. They reveal that the resulting abnormal insulin signaling in the offspring interferes with the formation of hypothalamic neural circuits that contribute to metabolic status.

Indexed as

Diet, High-FatLactationAnimalsFemaleHyperglycemiaHypothalamusInsulinMaleObesityPregnancyInsulin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.