Evidence map›Paper›PMID 24485410›Full record

ArticleAnnals of epidemiology2014

Diabetes predicts long-term disability in an elderly urban cohort: the Northern Manhattan Study.

Mandip S Dhamoon, Yeseon Park Moon, Myunghee C Paik, Ralph L Sacco, Mitchell S V Elkind

Open access · greenAbstract read
In one paragraph

Article in Annals of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Profiles of patients' self-reported health after acute stroke.Neurological research and practice · 2021
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  13. Incident Diabetes and Mobility Limitations: Reducing Bias Through Risk-set Matching.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mandip S DhamoonDepartment of Neurology, Mount Sinai School of Medicine, New York, NY. Electronic address: mandip.dhamoon@mssm.edu.
Yeseon Park MoonDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY.
Myunghee C PaikDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY.
Ralph L SaccoDepartment of Neurology, Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, FL; Department of Public Health Sciences and Human Genetics, Miller School of Medicine, University of Miami, FL; Department of Human Genetics, Miller School of Medicine, University of Miami, FL.
Mitchell S V ElkindDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY.
Columbia University · USIcahn School of Medicine at Mount Sinai · USUniversity of Miami · US

Funding

Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
Inflammatory and Infectious Burden and Risk of StrokeR01NS048134 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ELKIND, MITCHELL S · 2004 to 2008
$1.5M
The trajectory of functional status and quality of life before and after strokeK23NS079422 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DHAMOON, MANDIP SINGH · 2013 to 2017
$917k
NINDS NIH HHS K23 NS079422NINDS NIH HHS K23NS079422NINDS NIH HHS R01 NS048134NINDS NIH HHS R37 NS029993PHS HHS R3729993
6 · The paper itself

Abstract

purposeThere are limited data on vascular predictors of long-term disability in Hispanics. We hypothesized that (1) functional status declines over time and (2) vascular risk factors predict functional decline.

methodsThe Northern Manhattan Study contains a population-based study of 3298 stroke-free individuals aged 40 years or older, followed for median 11 years. The Barthel Index (BI) was assessed annually. Generalized estimating equations and Cox models were adjusted for demographic, medical, and social risk factors. Stroke and myocardial infarction occurring during follow-up were censored in sensitivity analysis. Secondarily, motor and nonmotor domains of the BI were analyzed.

resultsMean age (standard deviation) of the cohort (n = 3298) was 69.2 (10) years, 37% were male, 52% Hispanic, 22% diabetic, and 74% hypertensive. There was a mean annual decline of 1.02 BI points (P < .0001). Predictors of decline in BI included age, female sex, diabetes, depression, and normocholesterolemia. Results did not change with censoring. We found similar predictors of BI for motor and nonmotor domains.

conclusionIn this large, population-based, multiethnic study with long-term follow-up, we found a 1% mean decline in function per year that did not change when vascular events were censored. Diabetes predicted functional decline in the absence of clinical vascular events.

Indexed as

Activities of Daily LivingAdultAgedAged, 80 and overAge FactorsBlack or African AmericanDiabetes MellitusDisability EvaluationFemaleFollow-Up StudiesHispanic or LatinoHumansMaleMiddle AgedModels, StatisticalNew York CityDisabilityEpidemiologyStroke

Identifiers

PMID24485410
PMCPMC4011963
OpenAlexW2164586727

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.