ArticleClinical epigenetics2014
Differences in smoking associated DNA methylation patterns in South Asians and Europeans.
Article in Clinical epigenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 12 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
180 citing papers in PubMed, 12 syntheses or guidelines pooled it, 308 citations in OpenAlex.
- Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effects.Psychopharmacology · 2026Pooled it
- Epigenetic and blood markers associated with response to electroconvulsive therapy in patients with depressive disorders.Translational psychiatry · 2025Pooled it
- Epigenome-wide association study, meta-analysis, and multiscore profiling of whole blood in Parkinson's disease.Annals of clinical and translational neurology · 2025Pooled it
- Pooled it
- Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia.Molecular psychiatry · 2024Pooled it
- Decoding depression: a comprehensive multi-cohort exploration of blood DNA methylation using machine learning and deep learning approaches.Translational psychiatry · 2024Pooled it
- Risk Factors Associated with Nasopharyngeal Cancer Incidences in Indonesia: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2023Pooled it
- DNA methylation changes in cord blood and the developmental origins of health and disease - a systematic review and replication study.BMC genomics · 2022Pooled it
- Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.Genome biology · 2021Pooled it
- Pooled it
- Appraising the causal relevance of DNA methylation for risk of lung cancer.International journal of epidemiology · 2019Pooled it
- DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.American journal of human genetics · 2016Pooled it
- System-Specific Epigenetic Aging Signatures in Autistic Adults.bioRxiv : the preprint server for biology · 2026Article
- DNA methylation signatures associated with bipolar disorder in peripheral blood improve prediction models.EBioMedicine · 2026Article
- EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data.Epigenomics · 2026Article
- Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations.Nature communications · 2025Article
- DNA methylation-based clocks, tobacco smoking, and lung cancer risk.BMC medicine · 2025Article
- Exercise and Epigenetic Regulation in COPD: Current Evidence and Potential Mechanistic Pathways.International journal of molecular sciences · 2025Review
- Cross-country health inequality in the asthma burden: findings from the global burden of disease study 2021.BMC public health · 2025Article
- From ageing clocks to human digital twins in personalising healthcare through biological age analysis.NPJ digital medicine · 2025Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundDNA methylation is strongly associated with smoking status at multiple sites across the genome. Studies have largely been restricted to European origin individuals yet the greatest increase in smoking is occurring in low income countries, such as the Indian subcontinent. We determined whether there are differences between South Asians and Europeans in smoking related loci, and if a smoking score, combining all smoking related DNA methylation scores, could differentiate smokers from non-smokers.
resultsIllumina HM450k BeadChip arrays were performed on 192 samples from the Southall And Brent REvisited (SABRE) cohort. Differential methylation in smokers was identified in 29 individual CpG sites at 18 unique loci. Interaction between smoking status and ethnic group was identified at the AHRR locus. Ethnic differences in DNA methylation were identified in non-smokers at two further loci, 6p21.33 and GNG12. With the exception of GFI1 and MYO1G these differences were largely unaffected by adjustment for cell composition. A smoking score based on methylation profile was constructed. Current smokers were identified with 100% sensitivity and 97% specificity in Europeans and with 80% sensitivity and 95% specificity in South Asians.
conclusionsDifferences in ethnic groups were identified in both single CpG sites and combined smoking score. The smoking score is a valuable tool for identification of true current smoking behaviour. Explanations for ethnic differences in DNA methylation in association with smoking may provide valuable clues to disease pathways.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.