ArticleReproductive biology and endocrinology : RB&E2014
Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development.
Article in Reproductive biology and endocrinology : RB&E, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Nanopore long-read RNA sequencing reveals key genes regulating pre-hierarchical follicle development in the chicken ovary.Poultry science · 2026Article
- The immune microenvironment: a key regulator of ovarian function during ovarian aging.Frontiers in immunology · 2026Review
- Review
- Proteomics profiling reveals lipid metabolism abnormalities during oogenesis in unexplained recurrent pregnancy loss.Frontiers in immunology · 2024Article
- Comparative Tensile Properties and Collagen Patterns in Domestic Cat (Bioengineering (Basel, Switzerland) · 2023Article
- Utility of Matrix Metalloproteinases in the Diagnosis, Monitoring and Prognosis of Ovarian Cancer Patients.Cancer management and research · 2022Review
- Metalloproteases in gonad formation and ovulation.General and comparative endocrinology · 2021Review
- Downregulation of Extracellular Matrix and Cell Adhesion Molecules in Cumulus Cells of Infertile Polycystic Ovary Syndrome Women with and without Insulin Resistance.Cell journal · 2019Article
- Polymorphisms in MMP-14 and MMP-2 genes and ovarian cancer survival.Cancer biomarkers : section A of Disease markers · 2019Article
- Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Gelatin Binding Proteins in Reproductive Physiology.Indian journal of microbiology · 2016Review
- MMP-14 and CD44 in Epithelial-to-Mesenchymal Transition (EMT) in ovarian cancer.Journal of ovarian research · 2016Article
- Limited independent prognostic value of MMP-14 and MMP-2 expression in ovarian cancer.Diagnostic pathology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography.
methodsOvarian tissue collected from the archives of the Department of Pathology was examined and medical records and histopathology were reviewed. Follicular fluids were collected at the IVF-department and analyzed using zymography.
resultsMMP-14 and MMP-2 were increasingly found in the growing follicles and MMP-2 was highly expressed in the corpus luteum. Pro-MMP-2 was present in follicular fluid of IVF-patients.
conclusionsThe presence of MMP-14 and MMP-2 during human ovarian follicular development from the primordial follicle to the tertiary follicle and corpus luteum is confirmed, as was indicated by earlier animal studies following stimulation with gonadotrophins.
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