SynthesisBMJ clinical evidence2014
Febrile seizures.
Synthesis in BMJ clinical evidence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Symptomatic fever management in children: A systematic review of national and international guidelines.PloS one · 2021Pooled it
- Risk Factors for Initial Febrile Seizures in Pediatric Patients at Iranian Tertiary Hospitals (2019-2021): Retrospective Cross-Sectional Study.Iranian journal of child neurology · 2026Article
- Latent profile analysis of perceived vulnerability among parents of children with febrile seizures.Frontiers in pediatrics · 2025Article
- Adverse Effects Related to Paediatric Influenza Vaccination and Its Influence on Vaccination Acceptability. The FLUTETRA Study: A Survey Conducted in the Region of Murcia, Spain.Influenza and other respiratory viruses · 2024Article
- Impact of the Omicron Strain on Febrile Convulsions Requiring Hospitalization in Children: A Single-Center Observational Study.Pediatric reports · 2024Article
- Alterations in Rat Hippocampal Glutamatergic System Properties after Prolonged Febrile Seizures.International journal of molecular sciences · 2023Article
- Frequency and risk factors for febrile seizures during COVID-19 pandemic waves: an observational study.European journal of pediatrics · 2023Observational
- Etiological and risk factors in recurrent febrile seizures: Insights through EEG analysis.Qatar medical journal · 2023Article
- Xenon inhalation attenuates neuronal injury and prevents epilepsy in febrile seizure Sprague-Dawley pups.Frontiers in cellular neuroscience · 2023Article
- Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice.Frontiers in pharmacology · 2023Article
- Letter to the editor response.Journal of child neurology · 2022Article
- The Negative Association between Breastfeeding Duration and Infant Febrile Seizure: A Retrospective Case-Control Study.International journal of environmental research and public health · 2022Article
- Birth characteristics and risk of febrile seizures.Acta neurologica Scandinavica · 2021Article
- Association between Foramen Size and Febrile Seizure Status in the Pediatric Population: A Two-Center Retrospective Analysis.Journal of neurosciences in rural practice · 2020Article
- Febrile seizures: an overview.Drugs in context · 2018Review
- Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study.BioMed research international · 2018Article
- Febrile Seizure Risk after Vaccination in Children One to Five Months of Age.Pediatric neurology · 2017Article
- Childhood epilepsies: What should a pediatrician know?Neurosciences (Riyadh, Saudi Arabia) · 2017Review
- Everybody's Got the Fever…Be it Fahrenheit or Centigrade.Epilepsy currentsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSimple febrile seizures are generalised in onset and have a brief duration. The American Academy of Pediatrics defines this brief duration to be <15 minutes; whereas, in the UK, a maximum duration of 10 minutes is used. Simple febrile seizures do not occur more than once in 24 hours and resolve spontaneously. Complex febrile seizures are longer lasting, have focal symptoms (at onset or during the seizure), and can recur within 24 hours or within the same febrile illness. This review only deals with simple febrile seizures. About 2% to 5% of children in the US and Western Europe, and 6% to 9% of infants and children in Japan, will have experienced at least one febrile seizure by the age of 5 years. A very small number of children with simple febrile seizures may develop afebrile seizures, but simple febrile seizures are not associated with any permanent neurological deficits. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments given during episodes of fever in children (aged 6 months to 5 years) with one or more previous simple febrile seizures? We searched: Medline, Embase, The Cochrane Library, and other important databases up to July 2013 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
resultsWe found 4 RCTs or systematic reviews of RCTs that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
conclusionsIn this systematic review, we present information relating to the effectiveness and safety of the following interventions: intermittent anticonvulsants (clobazam, diazepam, lorazepam), antipyretic drug treatments (paracetamol, ibuprofen), and conservative measures (watchful waiting, physical antipyretic measures [tepid sponging, removing clothes, cooling room, direct fanning of child]).
Indexed as
Identifiers
24484859PMC3908738W4300112962What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.