ArticleJournal of inflammation (London, England)2014
Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria.
Article in Journal of inflammation (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Effects of Serum Vitamin D Levels and Vitamin D Supplementation on Urticaria: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Prospective Monitoring of Serum Values of CBC, Total IgE, Thyroid Findings, D-Dimer, Vitamin D, and Inflammatory Molecules CRP, ESR, and IL-6 and Clinical Features of Chronic Spontaneous Urticaria Patients During Antihistamine Treatment.International journal of molecular sciences · 2026Article
- VITAMIN D IN PATIENTS WITH INFLAMMATORY SKIN DISEASES.Acta clinica Croatica · 2025Review
- Association of low vitamin D level and full-term early-onset neonatal sepsis; a case-control study.Italian journal of pediatrics · 2024Article
- Associations of Gut and Circulating Microbiota with Circulating Vitamin DJournal of inflammation research · 2024Article
- New-onset chronic spontaneous urticaria post-COVID-19 vaccination-South African case series.The journal of allergy and clinical immunology. Global · 2023Article
- Practical Approach to Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Children.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases.Biomedicines · 2022Review
- Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population.Postepy dermatologii i alergologii · 2020Article
- The relationship between vitamin D and inflammatory markers in maintenance hemodialysis patients.International urology and nephrology · 2019Article
- Relationship between vitamin D and chronic spontaneous urticaria: a systematic review.Clinical and translational allergy · 2018Article
- Amelioration of patients with chronic spontaneous urticaria in treatment with vitamin D supplement.Clinical and molecular allergy : CMA · 2017Article
- Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis.Expert review of clinical immunology · 2016Review
- Severe vitamin D deficiency in patients with Kawasaki disease: a potential role in the risk to develop heart vascular abnormalities?Clinical rheumatology · 2016Article
- Effective treatment of different phenotypes of chronic urticaria with omalizumab: Case reports and review of literature.International journal of immunopathology and pharmacology · 2016Article
- Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute phase response in chronic spontaneous urticaria.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Refractory chronic spontaneous urticaria and permanent atrial fibrillation associated with dental infection: Mere coincidence or something more to it?International journal of immunopathology and pharmacology · 2016Article
- Vitamin D as a Marker for Disease Severity in Chronic Urticaria and Its Possible Role in Pathogenesis.Annals of dermatology · 2015Article
- Analysis of circulating vascular endothelial growth factor and its soluble receptors in patients with different forms of chronic urticaria.BioMed research international · 2015Article
- Association between Micronutrient Levels and Chronic Spontaneous Urticaria.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/insufficiency is associated with increased incidence and/or severity of immune-inflammatory disorders.
aimTo assess relationship between vitamin D status and C-reactive protein (CRP), a nonspecific inflammatory marker of CSU activity.
methodsConcentrations of CRP and 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status were measured in serum of CSU patients and compared with the healthy controls.
resultsSerum 25(OH)D concentration was significantly lower in CSU group as compared with the normal subjects. The prevalence of vitamin D deficiency (< 20 ng/ml) was significantly higher in patients with CSU than among normal population. There were no significant differences in prevalence of 25(OH)D insufficiency between the groups. Serum CRP concentrations were significantly higher in CSU patients as compared with the healthy subjects. There were no significant correlations between CRP and 25(OH)D concentrations in CSU patients.
conclusionsCSU is associated with lower serum 25(OH)D concentration and higher prevalence of its deficiency. The results failed to show any effect of vitamin D status on circulating CRP concentrations in CSU. A potential role of vitamin D in pathogenesis and/or additive therapy of CSU needs to be examined in other cohorts of CSU patients as well as in larger studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.