ArticleBMC genomics2014
The chromatin architectural proteins HMGD1 and H1 bind reciprocally and have opposite effects on chromatin structure and gene regulation.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Ultraviolet damage and repair maps inGenome research · 2025Article
- The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus.Chembiochem : a European journal of chemical biology · 2023Article
- The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response.Genes · 2022Review
- Broad domains of histone marks in the highly compactGenome research · 2022Article
- Chromatin Organization and Function inCells · 2021Review
- Histone Acetyltransferases and Stem Cell Identity.Cancers · 2021Review
- The embryonic linker histone dBigH1 alters the functional state of active chromatin.Nucleic acids research · 2020Article
- Liquid-Liquid Phase Separation of Histone Proteins in Cells: Role in Chromatin Organization.Biophysical journal · 2020Article
- Chromatin accessibility and the regulatory epigenome.Nature reviews. Genetics · 2019Review
- Chromatin conformation regulates the coordination between DNA replication and transcription.Nature communications · 2018Article
- Emerging roles of linker histones in regulating chromatin structure and function.Nature reviews. Molecular cell biology · 2018Review
- Article
- Comparative analysis of linker histone H1, MeCP2, and HMGD1 on nucleosome stability and target site accessibility.Scientific reports · 2016Article
- Histone H1 Limits DNA Methylation in Neurospora crassa.G3 (Bethesda, Md.) · 2016Article
- Linker histone H1 and protein-protein interactions.Biochimica et biophysica acta · 2016Review
- Involvement of PARP1 in the regulation of alternative splicing.Cell discovery · 2016Article
- The high mobility group protein HMO1 functions as a linker histone in yeast.Epigenetics & chromatin · 2016Article
- The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle.EMBO reports · 2015Review
- Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns.BMC genomics · 2015Article
- Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation.PloS one · 2015Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundChromatin architectural proteins interact with nucleosomes to modulate chromatin accessibility and higher-order chromatin structure. While these proteins are almost certainly important for gene regulation they have been studied far less than the core histone proteins.
resultsHere we describe the genomic distributions and functional roles of two chromatin architectural proteins: histone H1 and the high mobility group protein HMGD1 in Drosophila S2 cells. Using ChIP-seq, biochemical and gene specific approaches, we find that HMGD1 binds to highly accessible regulatory chromatin and active promoters. In contrast, H1 is primarily associated with heterochromatic regions marked with repressive histone marks. We find that the ratio of HMGD1 to H1 binding is a better predictor of gene activity than either protein by itself, which suggests that reciprocal binding between these proteins is important for gene regulation. Using knockdown experiments, we show that HMGD1 and H1 affect the occupancy of the other protein, change nucleosome repeat length and modulate gene expression.
conclusionCollectively, our data suggest that dynamic and mutually exclusive binding of H1 and HMGD1 to nucleosomes and their linker sequences may control the fluid chromatin structure that is required for transcriptional regulation. This study provides a framework to further study the interplay between chromatin architectural proteins and epigenetics in gene regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.