ArticleJournal of neurosurgery2014
Endogenous and exogenous hormone exposure and the risk of meningioma in men.
Article in Journal of neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Association between anthropometric factors and meningioma risk: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Body mass index and risk of brain tumors: a systematic review and dose-response meta-analysis.European journal of clinical nutrition · 2016Pooled it
- Pooled it
- Hormonal factors predisposing to the development of meningiomas in men: a case-control study.Journal of neuro-oncology · 2025Article
- Malignant Meningiomas: From Diagnostics to Treatment.Diagnostics (Basel, Switzerland) · 2025Review
- Grade-stratified meningioma risk among individuals who are non-Hispanic Black and interactions with male sex.Journal of the National Cancer Institute · 2025Article
- Association of thyroid disease and intracranial meningiomas: a retrospective analysis with external validation.Frontiers in oncology · 2025Article
- Meningioma: International Consortium on Meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients.Neuro-oncology · 2024Review
- Male sex and presence of preoperative symptoms are associated with early recurrence of WHO grade I meningiomas after surgical resection: analysis from the nationwide Brain Tumor Registry of Japan.Neurosurgical review · 2022Article
- Brain-invasive meningiomas: molecular mechanisms and potential therapeutic options.Brain tumor pathology · 2021Review
- A meta-analysis of active smoking and risk of meningioma.Tobacco induced diseases · 2021Review
- Sex-specific aspects of epidemiology, molecular genetics and outcome: primary brain tumours.ESMO open · 2020Review
- Risk factors for childhood and adult primary brain tumors.Neuro-oncology · 2019Review
- Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women.Cancer medicine · 2019Article
- Body mass index, comorbidities, and hormonal factors in relation to meningioma in an ethnically diverse population: the Multiethnic Cohort.Neuro-oncology · 2019Article
- Mendelian randomization provides support for obesity as a risk factor for meningioma.Scientific reports · 2019Article
- Pediatric infratentorial meningiomas: a series of 19 cases and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Metabolic syndrome in relation to risk of meningioma.Oncotarget · 2017Article
- Correlation of leptin receptor expression with BMI in differential grades of human meningiomas.Oncology letters · 2016Article
- Pathology and molecular genetics of meningioma: recent advances.Neurologia medico-chirurgica · 2015Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
objectMeningioma is a disease with considerable morbidity and is more commonly diagnosed in females than in males. Hormonally related risk factors have long been postulated to be associated with meningioma risk, but no examination of these factors has been undertaken in males.
methodsSubjects were male patients with intracranial meningioma (n = 456), ranging in age from 20 to 79 years, who were diagnosed among residents of the states of Connecticut, Massachusetts, and North Carolina, the San Francisco Bay Area, and 8 counties in Texas and matched controls (n = 452). Multivariate logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the association between hormonal factors and meningioma risk in men.
resultsUse of soy and tofu products was inversely associated with meningioma risk (OR 0.50 [95% CI 0.37-0.68]). Increased body mass index (BMI) appears to be associated with an approximately 2-fold increased risk of developing meningioma in men. No other single hormone-related exposure was found to be associated with meningioma risk, although the prevalence of exposure to factors such as orchiectomy and vasectomy was very low.
conclusionsEstrogen-like exogenous exposures, such as soy and tofu, may be associated with reduced risk of meningioma in men. Endogenous estrogen-associated factors such as high BMI may increase risk. Examination of other exposures related to these factors may lead to better understanding of mechanisms and potentially to intervention.
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Registered trials
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