Evidence map›Paper›PMID 24483949›Full record

ReviewEndocrine reviews2014

Chlorinated persistent organic pollutants, obesity, and type 2 diabetes.

Duk-Hee Lee, Miquel Porta, David R Jacobs, Laura N Vandenberg

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrine reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02675101 (Nuts and Olestra for Persistent Organic Pollutant Reduction), which is not on this map. Cited by 167 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 5 pooled it
29.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02675101 nacompletednot on this mapstarted 2016, after this paper: background citation

Nuts and Olestra for Persistent Organic Pollutant Reduction (NO-POPs) Trial: A Pilot Investigation

TypeinterventionalSponsorUniversity of California, San DiegoRan2016 to 2019Enrolled45ConditionsPersistent Organic Pollutants, Endocrine Disrupting Chemicals, Endocrine Disruptor EffectsArmsWhole Nuts, Olestra: Fat Free Pringles, Vegetable Oil: Original Pringles
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 5 syntheses or guidelines pooled it, 417 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Association between Exposure toEnvironmental health perspectives · 2017
    Pooled it
  5. Body burden of persistent organic pollutants on hypertension: a meta-analysis.Environmental science and pollution research international · 2016
    Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Review
  11. Review
  12. Organic Pollutants and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. The influence of endocrine disruptors on the gut microbiota.Turkish journal of medical sciences · 2025
    Review

107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 4 countries.

Duk-Hee LeeDepartment of Preventive Medicine (D.-H.L.), School of Medicine, Kyungpook National University, Daegu 700-422, Korea; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science (D.-H.L.), Kyungpook National University, Korea; Hospital del Mar Institute of Medical Research (M.P.), School of Medicine, Universitat Autonoma de Barcelona, and Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona 08193, Spain; Division of Epidemiology (D.R.J.), School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455; Department of Nutrition (D.R.J.), University of Oslo, 0313 Oslo, Norway; and University of Massachusetts-Amherst (L.N.V.), School of Public Health, Division of Environmental Health Sciences, Amherst, Massachusetts 01003.
Miquel Porta
David R Jacobs
Laura N Vandenberg
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESKyungpook National University · KRUniversity of Massachusetts Amherst · USUniversity of Oslo · NO

Funding

EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSISR01HL053560 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GROSS, MYRON D, JACOBS, DAVID R · 1995 to 2014
$9.0M
NHLBI NIH HHS R01 HL053560
6 · The paper itself

Abstract

Persistent organic pollutants (POPs) are lipophilic compounds that travel with lipids and accumulate mainly in adipose tissue. Recent human evidence links low-dose POPs to an increased risk of type 2 diabetes (T2D). Because humans are contaminated by POP mixtures and POPs possibly have nonmonotonic dose-response relations with T2D, critical methodological issues arise in evaluating human findings. This review summarizes epidemiological results on chlorinated POPs and T2D, and relevant experimental evidence. It also discusses how features of POPs can affect inferences in humans. The evidence as a whole suggests that, rather than a few individual POPs, background exposure to POP mixtures-including organochlorine pesticides and polychlorinated biphenyls-can increase T2D risk in humans. Inconsistent statistical significance for individual POPs may arise due to distributional differences in POP mixtures among populations. Differences in the observed shape of the dose-response curves among human studies may reflect an inverted U-shaped association secondary to mitochondrial dysfunction or endocrine disruption. Finally, we examine the relationship between POPs and obesity. There is evidence in animal studies that low-dose POP mixtures are obesogenic. However, relationships between POPs and obesity in humans have been inconsistent. Adipose tissue plays a dual role of promoting T2D and providing a relatively safe place to store POPs. Large prospective studies with serial measurements of a broad range of POPs, adiposity, and clinically relevant biomarkers are needed to disentangle the interrelationships among POPs, obesity, and the development of T2D. Also needed are laboratory experiments that more closely mimic real-world POP doses, mixtures, and exposure duration in humans.

Indexed as

AnimalsDiabetes Mellitus, Type 2Disease Models, AnimalEnvironmental PollutantsHumansHydrocarbons, ChlorinatedObesityOrganic ChemicalsPesticidesPolychlorinated BiphenylsRisk FactorsEnvironmental PollutantsHydrocarbons, ChlorinatedOrganic ChemicalsPesticidesPolychlorinated Biphenyls

Identifiers

PMID24483949
PMCPMC5393257
OpenAlexW1998007417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.