ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2013
Teardrop shapes minimize bending energy of fusion pores connecting planar bilayers.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Somatostatin modulation of initial fusion pores in CaThe Journal of physiology · 2025Article
- Lipid demixing reduces energy barriers for high-curvature vesicle budding.Biophysical journal · 2025Article
- Three membrane fusion pore families determine the pathway to pore dilation.Biophysical journal · 2023Article
- The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores.eLife · 2021Article
- Fusion Pore Expansion and Contraction during Catecholamine Release from Endocrine Cells.Biophysical journal · 2020Article
- Continuum Models of Membrane Fusion: Evolution of the Theory.International journal of molecular sciences · 2020Review
- SNARE-mediated membrane fusion arrests at pore expansion to regulate the volume of an organelle.The EMBO journal · 2018Article
- Article
- Palmitoylation Contributes to Membrane Curvature in Influenza A Virus Assembly and Hemagglutinin-Mediated Membrane Fusion.Journal of virology · 2017Article
- Fusion pores and their control of neurotransmitter and hormone release.The Journal of general physiology · 2017Review
- Calculating Transition Energy Barriers and Characterizing Activation States for Steps of Fusion.Biophysical journal · 2016Article
- How Viruses Invade Cells.Biophysical journal · 2016Review
- Elastic deformations of bolalipid membranes.Soft matter · 2016Article
- Free energy landscape of rim-pore expansion in membrane fusion.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A numerical gradient flow procedure was devised to characterize minimal energy shapes of fusion pores connecting two parallel planar bilayer membranes. Pore energy, composed of splay, tilt, and stretching, was obtained by modeling each bilayer as two monolayers and treating each monolayer of a bilayer membrane as a freely deformable surface described with a mean lipid orientation field. Voids between the two monolayers were prevented by a steric penalty formulation. Pore shapes were assumed to possess both axial and reflectional symmetry. For fixed pore radius and bilayer separation, the gradient flow procedure was applied to initially toroidal pore shapes. Using initially elliptical pore shapes yielded the same final shape. The resulting minimal pore shapes and energies were analyzed as a function of pore dimension and lipid composition. Previous studies either assumed or confined pore shapes, thereby tacitly supplying an unspecified amount of energy to maintain shape. The shapes derived in the present study were outputs of calculations and an externally provided energy was not supplied. Our procedure therefore yielded energy minima significantly lower than those reported in prior studies. The membrane of minimal energy pores bowed outward near the pore lumen, yielding a pore length that exceeded the distance between the two fusing membranes.
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