ArticleAlcoholism, clinical and experimental research2014
Event-related potential responses to the acute and chronic effects of alcohol in adolescent and adult Wistar rats.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Chronic alcohol-induced brain states limit propagation of direct cortical stimulation.Scientific reports · 2025Article
- Effects of daridorexant on rest/wake activity patterns and drinking in adult rats exposed to chronic ethanol vapor in adolescence.Alcohol (Fayetteville, N.Y.) · 2025Article
- Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction.Translational psychiatry · 2024Article
- Use of a Fitbit-like device in rats: Sex differences, relation to EEG sleep, and use to measure the long-term effects of adolescent ethanol exposure.Alcohol, clinical & experimental research · 2023Article
- Personalized Brain-Computer Interface and Its Applications.Journal of personalized medicine · 2022Review
- A Multimodal Neuroprosthetic Interface to Record, Modulate and Classify Electrophysiological Biomarkers Relevant to Neuropsychiatric Disorders.Frontiers in bioengineering and biotechnology · 2021Article
- PSPH-D-18-00526: Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence.Psychopharmacology · 2020Article
- Effects of an Orexin-2 Receptor Antagonist on Sleep and Event-Related Oscillations in Female Rats Exposed to Chronic Intermittent Ethanol During Adolescence.Alcoholism, clinical and experimental research · 2020Article
- Biomarkers and neuromodulation techniques in substance use disorders.Bioelectronic medicine · 2020Review
- CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms.Drug and alcohol dependence · 2019Article
- Article
- Effect of gabapentin on sleep and delta and theta EEG power in adult rats exposed to chronic intermittent ethanol vapor and protracted withdrawal during adolescence.Psychopharmacology · 2018Article
- Effects of adolescent alcohol consumption on the brain and behaviour.Nature reviews. Neuroscience · 2018Review
- Effect of Gabapentin on Sleep and Event-Related Oscillations (EROs) in Rats Exposed to Chronic Intermittent Ethanol Vapor and Protracted Withdrawal.Alcoholism, clinical and experimental research · 2018Article
- Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats.Alcohol (Fayetteville, N.Y.) · 2017Article
- Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior.Pharmacological reviews · 2016Review
- Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: a mini-review.Neuroscience and biobehavioral reviews · 2014Review
- Ontogeny and adolescent alcohol exposure in Wistar rats: open field conflict, light/dark box and forced swim test.Pharmacology, biochemistry, and behavior · 2014Article
- Associations between a history of binge drinking during adolescence and self-reported responses to alcohol in young adult Native and Mexican Americans.Alcoholism, clinical and experimental research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis study explored the hypothesis that adolescent ethanol (EtOH) exposure may cause long-lasting changes in EtOH sensitivity by exploring the age-related effects of acute alcohol on intoxication and on event-related potential (ERP) responses to acoustic stimuli in EtOH-naïve adolescent and adult male Wistar rats and in adult rats that were exposed to chronic EtOH/control conditions during adolescence.
methodsEtOH-naïve adolescent (postnatal day 32 [PD32]) and adult male rats (PD99) were included in the first study. In a second study, rats were exposed to 5 weeks of EtOH vapor (blood EtOH concentrations at 175 mg%) or air from PD24 to 59 and allowed to mature until PD90. In both studies, rats were implanted with cortical recording electrodes, and the effects of acute EtOH (0.0, 1.5, and 3.0 g/kg) on behavioral and ERP responses were assessed.
resultsAdolescents were found to have higher amplitude and longer latency P3a and P3b components at baseline as compared to adult rats, and EtOH was found to produce a robust dose-dependent increase in the latency of the P3a and P3b components of the auditory ERP recorded in cortical sites in both adolescents and adults. However, EtOH produced significantly larger delays in P3a and P3b latencies in adults as compared to adolescents. Acute EtOH administration was also found to produce a robust dose-dependent increase in the latency of the P3a and P3b components in adult animals exposed to EtOH vapor as adolescents and air exposed controls; however, larger acute EtOH-induced increases in P3a and P3b latencies were seen in controls as compared to adolescent vapor exposed rats.
conclusionsAdolescent rats have a less intense P3 latency response to acute EtOH administration when compared to adult rats. Exposure to chronic EtOH during adolescence can cause "retention" of the adolescent phenotype of reduced P3 latency sensitivity to EtOH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.