ArticleBiochimica et biophysica acta2014
Palmitate interaction with physiological states of myoglobin.
Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mutation-induced heme pocket destabilization in myoglobinopathy.Frontiers in bioinformatics · 2026Article
- Myoglobin inhibits breast cancer cell fatty acid oxidation and migration via heme-dependent oxidant production and not fatty acid binding.Free radical biology & medicine · 2024Article
- A versatile delivery vehicle for cellular oxygen and fuels or metabolic sensor? A review and perspective on the functions of myoglobin.Physiological reviews · 2024Review
- Review
- Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice.Scientific reports · 2023Article
- Pro-Apoptotic and Anti-Invasive Properties Underscore the Tumor-Suppressing Impact of Myoglobin on a Subset of Human Breast Cancer Cells.International journal of molecular sciences · 2022Article
- Myoglobin expression by alternative transcript in different mesenchymal stem cells compartments.Stem cell research & therapy · 2022Article
- Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells.PloS one · 2022Article
- On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Metabolic physiology and skeletal muscle phenotypes in male and female myoglobin knockout mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport.Redox biology · 2020Review
- Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin.Archives of biochemistry and biophysics · 2018Article
- Oxygen conserving mitochondrial adaptations in the skeletal muscles of breath hold divers.PloS one · 2018Article
- Differential Interaction of Myoglobin with Select Fatty Acids of Carbon Chain Lengths C8 to C16.Lipids · 2017Article
- A novel physiological role for cardiac myoglobin in lipid metabolism.Scientific reports · 2017Article
- Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease.Frontiers in physiology · 2017Review
- Novel Molecular Interactions of Acylcarnitines and Fatty Acids with Myoglobin.The Journal of biological chemistry · 2016Article
- Effect of fatty acid interaction on myoglobin oxygen affinity and triglyceride metabolism.Journal of physiology and biochemistry · 2016Article
- Myoglobin and the regulation of mitochondrial respiratory chain complex IV.The Journal of physiology · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies have shown that palmitate (PA) can bind specifically and non-specifically to Fe(III)MbCN. The present study has observed PA interaction with physiological states of Fe(II)Mb, and the observations support the hypothesis that Mb may have a potential role in facilitating intracellular fatty acid transport.
methods1H NMR spectra measurements of the Mb signal during PA titration show signal changes consistent with specific and non-specific binding.
resultsPalmitate (PA) interacts differently with physiological states of Mb. Deoxy Mb does not interact specifically or non-specifically with PA, while the carbonmonoxy myoglobin (MbCO) interaction with PA decreases the intensity of selective signals and produces a 0.15ppmupfield shift of the PAmethylene peak. The selective signal change upon PA titration provides a basis to determine an apparent PA binding constant,which serves to create a model comparing the competitive PA binding and facilitated fatty acid transport of Mb and fatty acid binding protein(FABP).
conclusionsGiven contrasting PA interaction of ligated vs. unligated Mb, the cellular fatty acid binding protein(FABP) and Mb concentration in the cell, the reported cellular diffusion coefficients, the PA dissociation constants from ligated Mb and FABP, a fatty acid flux model suggests that Mb can compete with FABP transporting cellular fatty acid. GENERAL SIGNIFICANCE: Under oxygenated conditions and continuous energy demand, Mb dependent fatty acid transport could influence the cell's preference for carbohydrate or fatty acid as a fuel source and regulate fatty acid metabolism.
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