Evidence map›Paper›PMID 24482742›Full record

ArticleJournal of chromatography & separation techniques2013

Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method.

Qing-Yi Lu, Lifeng Zhang, Aurelia Lugea, Aune Moro, Mouad Edderkaoui, Guido Eibl, Stephen J Pandol, Vay-Liang W Go

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of chromatography & separation techniques, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Qing-Yi LuDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Lifeng ZhangDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Aurelia LugeaDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA ; Veterans Affairs Greater Los Angeles Healthcare System, University of California, Los Angeles, CA, USA.
Aune MoroDepartment of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Mouad EdderkaouiDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA ; Veterans Affairs Greater Los Angeles Healthcare System, University of California, Los Angeles, CA, USA.
Guido EiblDepartment of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Stephen J PandolDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA ; Veterans Affairs Greater Los Angeles Healthcare System, University of California, Los Angeles, CA, USA.
Vay-Liang W GoDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · US

Funding

Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinomaP01CA163200 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EIBL, GUIDO ERWIN MICHAEL · 2012 to 2016
$6.2M
UCLA Center for Excellence in Pancreatic DiseasesP01AT003960 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GO, VAY LIANG W · 2007 to 2011
$5.6M
Alcohol abuse and Endoplasmic Reticulum dysfunction in exocrine pancreasR01AA019954 · NIAAA · CEDARS-SINAI MEDICAL CENTER · PI LUGEA, AURELIA · 2011 to 2015
$1.7M
The role of n-3 polyunsaturated fatty acids in pancreatic cancerR01CA122042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EIBL, GUIDO ERWIN MICHAEL · 2007 to 2011
$1.5M
NCCIH NIH HHS P01 AT003960NCI NIH HHS P01 CA163200NCI NIH HHS R01 CA122042NIAAA NIH HHS R01 AA019954
6 · The paper itself

Abstract

Rottlerin is a natural polyphenolic ketone isolated from the pericarps of Mallotus phillippinensis. In previous studies we showed that parenteral administration of rottlerin reduced tumor growth in murine xenograft models of pancreatic cancer. The aim of this study was to develop a simple and validated method for the quantitative determination of rottlerin in plasma and tumor tissues of mice fed a rottlerin diet. A xenograft model of pancreatic cancer was prepared by injection of 2×10

Indexed as

Cell uptakeHPLCIn vivoPancreatic cancerRottlerinTissue distribution

Identifiers

PMID24482742
PMCPMC3904376
OpenAlexW2027668401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.