ArticleInternational journal of clinical and experimental medicine2014
Therapeutic effect of transplanting bone mesenchymal stem cells on the hind limbs' motor function of rats with acute spinal cord injury.
Article in International journal of clinical and experimental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Mesenchymal Stem Cells for the Treatment of Spinal Cord Injury in Rat Models: A Systematic Review and Network Meta-Analysis.Cell transplantationPooled it
- Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β.Experimental and therapeutic medicine · 2017Article
- Epigallocatechin-3-gallate Protects against Hydrogen Peroxide-Induced Inhibition of Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.Stem cells international · 2016Article
- Superparamagnetic iron oxide promotes osteogenic differentiation of rat adipose-derived stem cells.International journal of clinical and experimental medicine · 2015Article
- Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury.Neural regeneration research · 2014Article
- Stem cell therapy in spinal trauma: Does it have scientific validity?Indian journal of orthopaedicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo research the therapeutic effect of the allograft of bone mesenchymal stem cells (BMSCs) on hind limbs' motor function of rats that underwent acute injury to their spinal nerve.
design40 Wistar rat samples with the acute injury to the spinal cord were established and divided into the transplantation group and the control group, 20 for each group; One week after injury, BMSCs were slowly injected into the center of the injured spinal cord of the rats, and the physiological saline was injected into the control group.
main outcome measuresThe rehabilitation of the motor function of the rats' hind limbs was observed; furthermore, eight weeks after the injury, the protein disparity of the nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) between the two groups of rats was noted.
resultsThe rehabilitation of the hind limbs' motor function of the transplantation group was significantly better than that of the control group from the third week on after injury, and the difference was of significance (P<0.05).
conclusionsTransplanting BMSCs can boost the protein expression of NGF and BDNF in the rats which undergo acute injury to their spinal nerves. It can, therefore, significantly improve the rehabilitation of the motor function of their hind limbs. The improvement is associated with the transplantation of BMSCs which are beneficial for regeneration and repair of the rat's spinal nerves.
Indexed as
Identifiers
24482714PMC3902266W333234688What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.