Trial reportPloS one2014
Sleep extension improves neurocognitive functions in chronically sleep-deprived obese individuals.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00261898 (Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity
Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- A Randomized Pilot Cognitive Behavioral Sleep Health Trial for Young Adults with Type 1 Diabetes.Behavioral sleep medicineTrial
- Executive Function Response to Moderate-to-High-Intensity Rope Skipping in Overweight Adolescents Aged 12-14: A Preliminary Study.Journal of functional morphology and kinesiology · 2025Article
- Article
- Article
- Potential Benefits of Daytime Naps on Consecutive Days for Motor Adaptation Learning.Clocks & sleep · 2022Article
- Sleep Extension: A Potential Target for Obesity Treatment.Current diabetes reports · 2020Review
- Sleep-related disorders in patients with type 1 diabetes mellitus: current insights.Nature and science of sleep · 2020Review
- Sleep Hygiene for Optimizing Recovery in Athletes: Review and Recommendations.International journal of sports medicine · 2019Review
- Short sleep duration and cardiometabolic risk: from pathophysiology to clinical evidence.Nature reviews. Cardiology · 2019Review
- Effects of Sleep Deprivation on Surgeons Dexterity.Frontiers in neurology · 2019Review
- Neurobehavioral Effects and Biomarkers of Sleep Loss in Healthy Adults.Current neurology and neuroscience reports · 2017Review
- The Association between Sleep Duration and Overweight in a School-Age Population in Seoul (J Obes Metab Syndr 2017;26:45-51).Journal of obesity & metabolic syndrome · 2017Article
- Poor sleep quality and later sleep timing are risk factors for osteopenia and sarcopenia in middle-aged men and women: The NEO study.PloS one · 2017Article
- The Development of a Clinically Relevant Sleep Modification Protocol for Youth with Type 1 Diabetes.Clinical practice in pediatric psychology · 2016Article
- Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology.Frontiers in immunology · 2016Review
- Sleep Deficiency is a Modifiable Risk Factor for Obesity and Cognitive Impairment and Associated with Elevated Visfatin.Open access Macedonian journal of medical sciences · 2015Article
- Article
- Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research.Perspectives on psychological science : a journal of the Association for Psychological Science · 2015Review
- The effects of extended bedtimes on sleep duration and food desire in overweight young adults: a home-based intervention.Appetite · 2014Article
- Association Between Sleep and Cognition of Older Adults in Rural Areas: A Cross-Sectional Study.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundSleep deprivation and obesity, are associated with neurocognitive impairments. Effects of sleep deprivation and obesity on cognition are unknown, and the cognitive long-term effects of improvement of sleep have not been prospectively assessed in short sleeping, obese individuals.
objectiveTo characterize neurocognitive functions and assess its reversibility.
designProspective cohort study.
settingTertiary Referral Research Clinical Center. PATIENTS: A cohort of 121 short-sleeping (<6.5 h/night) obese (BMI 30-55 kg/m(2)) men and pre-menopausal women.
interventionSleep extension (468±88 days) with life-style modifications. MEASUREMENTS: Neurocognitive functions, sleep quality and sleep duration.
resultsAt baseline, 44% of the individuals had an impaired global deficit score (t-score 0-39). Impaired global deficit score was associated with worse subjective sleep quality (p = 0.02), and lower urinary dopamine levels (p = 0.001). Memory was impaired in 33%; attention in 35%; motor skills in 42%; and executive function in 51% of individuals. At the final evaluation (N = 74), subjective sleep quality improved by 24% (p<0.001), self-reported sleep duration increased by 11% by questionnaires (p<0.001) and by 4% by diaries (p = 0.04), and daytime sleepiness tended to improve (p = 0.10). Global cognitive function and attention improved by 7% and 10%, respectively (both p = 0.001), and memory and executive functions tended to improve (p = 0.07 and p = 0.06). Serum cortisol increased by 17% (p = 0.02). In a multivariate mixed model, subjective sleep quality and sleep efficiency, urinary free cortisol and dopamine and plasma total ghrelin accounted for 1/5 of the variability in global cognitive function. LIMITATIONS: Drop-out rate.
conclusionsChronically sleep-deprived obese individuals exhibit substantial neurocognitive deficits that are partially reversible upon improvement of sleep in a non-pharmacological way. These findings have clinical implications for large segments of the US population. TRAIL REGISTRATION: www.ClinicalTrials.gov NCT00261898. NIDDK protocol 06-DK-0036.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.