ArticleNucleic acids research2014
A bacteriophage transcription regulator inhibits bacterial transcription initiation by σ-factor displacement.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- A previously undescribed archaeal virus suppresses host immunity.EMBO reports · 2025Article
- Coevolution between marine Aeromonas and phages reveals temporal trade-off patterns of phage resistance and host population fitness.The ISME journal · 2023Article
- Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel.Nucleic acids research · 2021Article
- The σ Subunit-Remodeling Factors: An Emerging Paradigms of Transcription Regulation.Frontiers in microbiology · 2020Review
- Structural basis for transcription antitermination at bacterial intrinsic terminator.Nature communications · 2019Article
- Zinc Finger Artificial Transcription Factor-Mediated Chloroplast Genome Interrogation in Arabidopsis thaliana.Plant & cell physiology · 2019Article
- A novel RNA polymerase-binding protein that interacts with a sigma-factor docking site.Molecular microbiology · 2017Article
- The Xp10 Bacteriophage Protein P7 Inhibits Transcription by the Major and Major Variant Forms of the Host RNA Polymerase via a Common Mechanism.Journal of molecular biology · 2016Article
- Local and global regulation of transcription initiation in bacteria.Nature reviews. Microbiology · 2016Review
- AFNMR: automated fragmentation quantum mechanical calculation of NMR chemical shifts for biomolecules.Journal of biomolecular NMR · 2015Article
- Bacteriophage Xp10 anti-termination factor p7 induces forward translocation by host RNA polymerase.Nucleic acids research · 2015Article
- Structural and biochemical investigation of bacteriophage N4-encoded RNA polymerases.Biomolecules · 2015Review
- Distinct pathways of RNA polymerase regulation by a phage-encoded factor.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The sabotage of the bacterial transcription machinery by a small bacteriophage protein.Bacteriophage · 2014Article
- Article
- Transcription regulation mechanisms of bacteriophages: recent advances and future prospects.BioengineeredReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Bacteriophages (phages) appropriate essential processes of bacterial hosts to benefit their own development. The multisubunit bacterial RNA polymerase (RNAp) enzyme, which catalyses DNA transcription, is targeted by phage-encoded transcription regulators that selectively modulate its activity. Here, we describe the structural and mechanistic basis for the inhibition of bacterial RNAp by the transcription regulator P7 encoded by Xanthomonas oryzae phage Xp10. We reveal that P7 uses a two-step mechanism to simultaneously interact with the catalytic β and β' subunits of the bacterial RNAp and inhibits transcription initiation by inducing the displacement of the σ(70)-factor on initial engagement of RNAp with promoter DNA. The new mode of interaction with and inhibition mechanism of bacterial RNAp by P7 underscore the remarkable variety of mechanisms evolved by phages to interfere with host transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.