ArticleMovement disorders : official journal of the Movement Disorder Society2014
Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06991816 (The Brain&Senses Study Impact of Multi Sensory Impairments on the Progression of Cognitive Decline and Reduction of Quality of Life in People Over 50ies), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Brain&Senses Study Impact of Multi Sensory Impairments on the Progression of Cognitive Decline and Reduction of Quality of Life in People Over 50ies
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Associations between olfactory dysfunction and structural MRI findings in Parkinson's disease: a systematic review.Brain imaging and behavior · 2026Pooled it
- Clinical features and neurobiochemical mechanisms of olfactory dysfunction in patients with Parkinson disease.Journal of neurology · 2024Article
- Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration.International journal of molecular sciences · 2024Article
- Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders.Frontiers in neuroscience · 2024Review
- Interactive effect of orthostatic hypotension on gray matter atrophy associated with hyposmia and RBD in de novo Parkinson's disease.Journal of neurology · 2023Article
- Olfactory Dysfunction in Parkinson's Disease, Its Functional and Neuroanatomical Correlates.NeuroSci · 2023Review
- Subjective Impairments in Olfaction and Cognition Predict Dissociated Behavioral Outcomes.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Simulating the progression of brain structural alterations in Parkinson's disease.NPJ Parkinson's disease · 2022Article
- Does Olfactory Dysfunction Correlate with Disease Progression in Parkinson's Disease? A Systematic Review of the Current Literature.Brain sciences · 2022Review
- The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults.Frontiers in aging neuroscience · 2022Article
- Unilateral Choanal Atresia: Indications of Long-Term Olfactory Deficits and Volumetric Brain Changes Postsurgically.ORL; journal for oto-rhino-laryngology and its related specialties · 2022Article
- Odor Identification and Regional Gray Matter Atrophy in Patients with Alzheimer's Disease, Parkinson's Disease, and the Healthy Elderly: A Cross-Sectional Structural MRI Study.Brain sciences · 2021Article
- Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson's Disease.International journal of molecular sciences · 2021Review
- Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson's disease.Molecular psychiatry · 2021Article
- The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease.Translational neurodegeneration · 2020Review
- The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's diseases.Translational neurodegeneration · 2020Review
- Association between Olfactory Deficit and Motor and Cognitive Function in Parkinson's Disease.Journal of movement disorders · 2020Article
- Perturbation of in vivo Neural Activity Following α-Synuclein Seeding in the Olfactory Bulb.Journal of Parkinson's disease · 2020Article
- Olfactory bulb surroundings can help to distinguish Parkinson's disease from non-parkinsonian olfactory dysfunction.NeuroImage. Clinical · 2020Article
- Association of olfaction dysfunction with brain microstructure in prodromal Parkinson disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Article
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6 authors at 2 institutions in 1 country.
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Abstract
backgroundOlfactory dysfunction is often associated with Parkinson's disease (PD) and can precede characteristic motor symptoms by several years. Olfactory-related cortical atrophy has been reported in PD, although the extent and association between cortical atrophy and olfactory dysfunction have been controversial. The present study examined whether olfactory dysfunction is associated with gray matter (GM) volume in brain regions subserving primary and secondary olfactory processing.
methodsHigh-resolution T1-weighted brain MRIs were acquired from 40 PD without dementia and 40 matched controls along with smell identification scores. Brain volumes were compared using voxel-based morphometry.
resultsCompared to controls, PD patients sustained greater GM loss localized to bilateral piriform cortex (PC) and orbitofrontal cortex (OFC). Reduced olfactory performance in PD was significantly associated with lower GM volumes in PC and OFC.
conclusionsBoth primary and secondary olfactory cortical atrophy occurred in PD and were associated with olfactory dysfunction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.