ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Mechanical interactions between adjacent airways in the lung.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Mechanical Power and Driving Pressure: Mechanisms of Lung Injury, Markers of Pathophysiology, or Therapeutic Targets?Journal of clinical medicine · 2025Article
- Modeling Ventilator-Induced Lung Injury and Neutrophil Infiltration to Infer Injury Interdependence.Annals of biomedical engineering · 2023Article
- Early Endothelial Signaling Transduction in Developing Lung Edema.Life (Basel, Switzerland) · 2023Review
- The impact of heterogeneity of the air-blood barrier on control of lung extravascular water and alveolar gas exchange.Frontiers in network physiology · 2023Review
- Spatiotemporal distribution of cellular injury and leukocytes during the progression of ventilator-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Perioperative Pulmonary Atelectasis: Part I. Biology and Mechanisms.Anesthesiology · 2022Review
- Percolation of collagen stress in a random network model of the alveolar wall.Scientific reports · 2021Article
- Measurement of the Total Lung Volume Using an Adjusted Single-Breath Helium Dilution Method in Patients With Obstructive Lung Disease.Frontiers in medicine · 2021Article
- The micromechanics of lung alveoli: structure and function of surfactant and tissue components.Histochemistry and cell biology · 2018Review
- A Distribution-Moment Approximation for Coupled Dynamics of the Airway Wall and Airway Smooth Muscle.Biophysical journal · 2018Article
- Elevation in lung volume and preventing catastrophic airway closure in asthmatics during bronchoconstriction.PloS one · 2018Article
- Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma.American journal of respiratory and critical care medicine · 2017Article
- Systems physiology of the airways in health and obstructive pulmonary disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Modeling the Progression of Epithelial Leak Caused by Overdistension.Cellular and molecular bioengineering · 2016Article
- Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices: Toward anFrontiers in physiology · 2016Article
- Resistance to alveolar shape change limits range of force propagation in lung parenchyma.Respiratory physiology & neurobiology · 2015Article
- Spatial pattern formation in the lung.Journal of mathematical biology · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The forces of mechanical interdependence between the airways and the parenchyma in the lung are powerful modulators of airways responsiveness. Little is known, however, about the extent to which adjacent airways affect each other's ability to narrow due to distortional forces generated within the intervening parenchyma. We developed a two-dimensional computational model of two airways embedded in parenchyma. The parenchyma itself was modeled in three ways: 1) as a network of hexagonally arranged springs, 2) as a network of triangularly arranged springs, and 3) as an elastic continuum. In all cases, we determined how the narrowing of one airway was affected when the other airway was relaxed vs. when it narrowed to the same extent as the first airway. For the continuum and triangular network models, interactions between airways were negligible unless the airways lay within about two relaxed diameters of each other, but even at this distance the interactions were small. By contrast, the hexagonal spring network model predicted that airway-airway interactions mediated by the parenchyma can be substantial for any degree of airway separation at intermediate values of airway contraction forces. Evidence to date suggests that the parenchyma may be better represented by the continuum model, which suggests that the parenchyma does not mediate significant interactions between narrowing airways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.