Evidence map›Paper›PMID 24481855›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2015

Evaluation of the novel near-infrared fluorescence tracers pullulan polymer nanogel and indocyanine green/γ-glutamic acid complex for sentinel lymph node navigation surgery in large animal models.

Seong-Ho Kong, Young-Woock Noh, Yun-Suhk Suh, Hye Sun Park, Hyuk-Joon Lee, Keon Wook Kang, Hee Chan Kim, Yong Taik Lim, Han-Kwang Yang

Registry-linked trialOpen access · bronzeAbstract readComparative StudyEvaluation Study
PubMed Publisher
In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03024892 (Intra-gallbladder or Systemic Indocyanide Green Injection Facilitate Cholecystectomy in Acute Cholecystitis , Gallstone and Gallbladder Polyp Patients.), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03024892 naunknown statusnot on this map

Intra-gallbladder or Systemic Indocyanide Green Injection Facilitate Cholecystectomy in Acute Cholecystitis , Gallstone and Gallbladder Polyp Patients.

TypeinterventionalSponsorChang Gung Memorial HospitalRan2015 to 2018Enrolled600ConditionsFluorenscent Image Guided Surgery, Indocyanide GreenArmsICG GB, ICG IV, LC conventional, LC conventional and IOC
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 60 citations in OpenAlex.

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  14. [Fluorescence-guided detection of lymph node metastases of gastrointestinal tumors].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Seong-Ho KongDepartment of Surgery, Seoul National University Hospital, Seoul, Korea.
Young-Woock Noh
Yun-Suhk Suh
Hye Sun Park
Hyuk-Joon Lee
Keon Wook Kang
Hee Chan Kim
Yong Taik Lim
Han-Kwang Yang
Seoul National University Hospital · KRKorea Basic Science Institute · KRKorea Research Institute of Bioscience and Biotechnology · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to examine tracers designed to overcome the disadvantages of indocyanine green (ICG), which disperses quickly to multiple lymph nodes, using a near-infrared (NIR) imaging system in animal models.

methodsDiluted ICG, ICG/poly-γ-glutamic acid (PGA) complex, and IRDye900-conjugated pullulan-cholesterol nanoprobe "near-infrared polynagogel" (NIR-PNG) were injected into the stomachs of dogs and pigs, and the patterns of dispersion were observed using an NIR imaging system. To compare retention times, fluorescence signals were evaluated in the stomach and small bowel of animals 1 week after injection.

resultsA diluted concentration (~0.1 mg/ml) of ICG was optimal for NIR imaging compared with the conventional concentration (5 mg/ml) for visual inspection. When injected into the stomach, the signals of ICG and ICG/PGA complex were relatively large at the injection site, and signals were detected at multiple sentinel nodes and lymph nodes beyond them. The NIR-PNG signal intensity was relatively small at the injection site and limited to only one sentinel node with no additional node. When evaluated 1 week after injection, only the NIR-PNG signal was detected in the canine stomach, and the signal intensity at the lymph nodes of the porcine small bowel was the highest with NIR-PNG, followed by ICG/PGA complex and finally ICG.

conclusionNIR-PNG showed the best characteristics of less dispersion and longer retention in the sentinel nodes, and ICG/PGA complex remained longer than diluted ICG. These tracers could potentially be used as optimal tracers for sentinel node navigation surgery in gastric cancer.

Indexed as

GlucansIndocyanine GreenAnimalsDiagnostic ImagingDisease Models, AnimalDogsFemaleFluorescent DyesIntestinesLymphatic MetastasisLymph NodesMice, Inbred BALB CNanostructuresPolyglutamic AcidQuantum DotsSentinel Lymph Node BiopsyFluorescent DyesGlucansIndocyanine GreenPolyglutamic Acidpullulan

Identifiers

PMID24481855
OpenAlexW1970513137

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.