ArticleMetabolic brain disease2014
Determinants of cognitive performance in children relying on cyanogenic cassava as staple food.
Article in Metabolic brain disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Acceptability of Vegetable FortifiedNutrients · 2021Article
- Preclinical and clinical research on the toxic and neurological effects of cassava (Manihot esculenta Crantz) consumption.Metabolic brain disease · 2020Review
- Chronic consumption of cassava juice induces cellular stress in rat substantia nigra.Iranian journal of basic medical sciences · 2020Article
- Cognitive and motor performance in Congolese children with konzo during 4 years of follow-up: a longitudinal analysis.The Lancet. Global health · 2017Article
- Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning.Neurotoxicology · 2017Article
- Cyanide and the human brain: perspectives from a model of food (cassava) poisoning.Annals of the New York Academy of Sciences · 2016Review
- Serum 8,12-iso-iPF2α-VI isoprostane marker of oxidative damage and cognition deficits in children with konzo.PloS one · 2014Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
While risk factors for konzo are known, determinants of cognitive impairment in konzo-affected children remain unknown. We anchored cognitive performance (KABC-II scores) to serum levels of free-thyroxine (free-T4), thyroid-stimulating hormone (TSH), albumin, and motor proficiency (BOT-2 scores) in 40 children including 21 with konzo (median age: 9 years) and 19 without konzo (median age: 8 years). A multiple regression model was used to determine variables associated with changes in KABC-II scores. Age (β: -0.818, 95% CI: -1.48, -0.152) (p = 0.018), gender (β: -5.72; 95% CI: -9.87, -1.57 for females) (p = 0.009), BOT-2 score (β: 0.390; 95% CI: 0.113, 0.667) (p = 0.008), and free-T4 (β: 1.88; 95% CI: 0.009, 3.74) (p = 0.049) explained 61.1 % of variation in KABC-II scores. Subclinical hypothyroidism was not associated with poor cognition. A crude association was found between serum albumin and KABC-II scores (β: 1.26; 95 % CI: 0.136, 2.39) (p = 0.029). On spot urinary thiocyanate reached 688 μmol/l in children without konzo and 1,032 μmol/L in those with konzo. Female gender and low serum albumin are risk factors common to cognitive and proportionally associated motor deficits in children exposed to cassava cyanogens. The two types of deficits may share common mechanisms.
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