Evidence map›Paper›PMID 24481678›Full record

ArticleMolecular neurobiology2014

Neural stem cell transplants improve cognitive function without altering amyloid pathology in an APP/PS1 double transgenic model of Alzheimer's disease.

Wei Zhang, Pei-Jun Wang, Hong-ying Sha, Jiong Ni, Ming-hua Li, Guo-jun Gu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Article
  6. Proposed Mechanisms of Cell Therapy for Alzheimer's Disease.International journal of molecular sciences · 2024
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  9. Mitochondria in Cell-Based Therapy for Stroke.Antioxidants (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei ZhangDepartment of Medical Imaging, Tongji Hospital, Medical School of Tongji University, No. 389 Xincun Road, Putuo District, Shanghai, 200065, China.
Pei-Jun Wang
Hong-ying Sha
Jiong Ni
Ming-hua Li
Guo-jun Gu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural stem cells (NSCs) are capable of self-renewal and are multipotent. Transplantation of NSCs may represent a promising approach for treating neurodegenerative disorders associated with cognitive decline, such as Alzheimer disease (AD) characterized by extensive loss of neurons. In this study, we investigated the effect of NSC transplantation on cognitive function in the amyloid precursor protein/presenilin-1 (APP/PS1) transgenic mouse, an AD mouse model with age-dependent cognitive deficits. We found that NSCs bilaterally transplanted into hippocampal regions improved spatial learning and memory function in these mice, but did not alter Aβ pathology. Immunohistochemical analyses determined that NSCs proliferated, migrated, and differentiated into three neuronal cell types. The improvement in cognitive function was correlated with enhanced long-term potentiation (LTP) and an increase in the neuron expression of proteins related to cognitive function: N-methyl-D-aspartate (NMDA) 2B unit, synaptophysin (SYP), protein kinase C ζ subtypes (PKCζ), tyrosine receptor kinase B (TrkB), and brain-derived neurotrophic factor (BDNF). Taken together, our data indicated that injected NSCs can rescue cognitive deficits in APP/PS1 transgenic mice by replacing neuronal cell types expressing multiple cognition-related proteins that enhance LTP.

Indexed as

Stem Cell TransplantationAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsBrain-Derived Neurotrophic FactorCell- and Tissue-Based TherapyCognitionDisease Models, AnimalLong-Term PotentiationMemoryMiceMice, TransgenicNeural Stem CellsNeuronsPresenilin-1Amyloid beta-Protein PrecursorBrain-Derived Neurotrophic FactorPresenilin-1presenilin 1, mouse

Identifiers

PMID24481678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.