Evidence map›Paper›PMID 24481333›Full record

Trial reportAJNR. American journal of neuroradiology2014

Bioactive versus bare platinum coils in the treatment of intracranial aneurysms: the MAPS (Matrix and Platinum Science) trial.

C G McDougall, S Claiborne Johnston, A Gholkar, S L Barnwell, J C Vazquez Suarez, J Massó Romero, J C Chaloupka, A Bonafe, A K Wakhloo, D Tampieri and 6 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02982200 (The MEDINA Study), which is not on this map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02982200 terminatednot on this mapstarted 2016, after this paper: background citation

The MEDINA Study: Medina Embolization Device In Neurovascular Aneurysms Study - A Post Market Clinical Follow-up Study

TypeobservationalSponsorMedtronic Neurovascular Clinical AffairsRan2016 to 2018Enrolled15ConditionsIntracranial Aneurysm
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  11. Embolization with larger-caliber coils can increase packing density: Evidence from the pilot phase of a randomized trial.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2017
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  12. Endovascular treatment of aneurysms and platinum coil caliber: Study protocol of a randomized, controlled trial.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2016
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  19. Literature review and DELPHI consensus on follow-up and retreatment of intracranial aneurysms with intrasaccular devices.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

C G McDougallFrom the Department of Neurosurgery (C.G.M.), Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona neuropub@dignityhealth.org.
S Claiborne JohnstonClinical and Translational Science Institute (S.C.J.).
A GholkarDepartment of Neuroradiology (A.G.), Regional Neurosciences Center, Royal Victoria Infirmary, Newcastle Upon Tyne, UK.
S L BarnwellDepartments of Neurological Surgery and Diagnostic Radiology (S.L.B.), Oregon Health and Science University, Portland, Oregon.
J C Vazquez SuarezTherapeutic Neuroradiology Unit (J.C.V.S.), University General Hospital of Alicante, Alicante, Spain.
J Massó RomeroDepartment of Interventional Neuroradiology (J.M.R.), Hospital Donostia, San Sebastián, Spain.
J C ChaloupkaDepartment of Neurosurgery and Radiology (J.C.C.), Mount Sinai Medical Center, Miami Beach, Florida.
A BonafeService de Neuroradiologie (A.B.), Hôspital Gui de Chauliac, Montpellier Cedex, France.
A K WakhlooDivision of Neuroimaging and Intervention (A.K.W.), Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts.
D TampieriDepartment of Diagnostic and Interventional Neuroradiology (D.T.), Montreal Neurological Institute, Montreal, Canada.
C F DowdDepartment of Radiology (C.F.D.), University of California, San Francisco, San Francisco, California.
A J FoxDepartment of Neuroradiology (A.J.F.), Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.
S J ImmStryker Corporation (S.J.I., K.C.), Fremont, California.
K CarrollStryker Corporation (S.J.I., K.C.), Fremont, California.
A S TurkDepartments of Neurointerventional Surgery, Radiology, and Neurosurgery (A.S.T.), Medical University of South Carolina, Charleston, South Carolina.
MAPS Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe ability of polymer-modified coils to promote stable aneurysm occlusion after endovascular treatment is not well-documented. Angiographic aneurysm recurrence is widely used as a surrogate for treatment failure, but studies documenting the correlation of angiographic recurrence with clinical failure are limited. This trial compares the effectiveness of Matrix(2) polyglycolic/polylactic acid biopolymer-modified coils with bare metal coils and correlates the angiographic findings with clinical failure (ie, target aneurysm recurrence), a composite end point that includes any incident of posttreatment aneurysm rupture, retreatment, or unexplained death. MATERIALS AND

methodsThis was a multicenter randomized noninferiority trial with blinded end point adjudication. We enrolled 626 patients, divided between Matrix(2) and bare metal coil groups. The primary outcome was target aneurysm recurrence at 12 ± 3 months.

resultsAt 455 days, at least 1 target aneurysm recurrence event had occurred in 14.6% of patients treated with bare metal coils and 13.3% of Matrix(2) (P = .76, log-rank test) patients; 92.8% of target aneurysm recurrence events were re-interventions for aneurysms that had not bled after treatment, and 5.8% of target aneurysm recurrence events resulted from hemorrhage or rehemorrhage, with or without retreatment. Symptomatic re-intervention occurred in only 4 (0.6%) patients. At 455 days, 95.8% of patients with unruptured aneurysms and 90.4% of those with ruptured aneurysms were independent (mRS ≤ 2). Target aneurysm recurrence was associated with incomplete initial angiographic aneurysm obliteration, presentation with rupture, and a larger aneurysmal dome and neck size.

conclusionsTested Matrix(2) coils were not inferior to bare metal coils. Endovascular coiling of intracranial aneurysms was safe, and the rate of technical success was high. Target aneurysm recurrence is a promising clinical outcome measure that correlates well with established angiographic measurements.

Indexed as

AdolescentAdultAgedAged, 80 and overCoated Materials, BiocompatibleEmbolization, TherapeuticEquipment Failure AnalysisExtracellular MatrixFemaleHumansIncidenceInternationalityIntracranial AneurysmMaleMiddle AgedPlatinumCoated Materials, BiocompatiblePlatinum

Identifiers

PMID24481333
PMCPMC7964535

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.