ArticleAJNR. American journal of neuroradiology2014
Mapping of glycine distributions in gliomas.
Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate and Glycine in Adult Subjects With Brainstem Gliomas.NMR in biomedicine · 2025Article
- The Multi-Voxel MRS of Glioma: Glycine is a Suitable Biomarker for Tumor Grading.Advanced biomedical research · 2025Article
- Article
- Proton metabolic mapping of the brain at 7 T using a two-dimensional free induction decay-echo-planar spectroscopic imaging readout with lipid suppression.NMR in biomedicine · 2022Article
- The Distribution of Major Brain Metabolites in Normal Adults: Short Echo Time Whole-Brain MR Spectroscopic Imaging Findings.Metabolites · 2022Article
- Optimization of spectrally selective 180° radiofrequency pulse timings in J-difference editing (MEGA) of lactate.Magnetic resonance in medicine · 2022Article
- Emerging MR Imaging and Spectroscopic Methods to Study Brain Tumor Metabolism.Frontiers in neurology · 2022Review
- Accelerated MR spectroscopic imaging-a review of current and emerging techniques.NMR in biomedicine · 2021Review
- Emerging MRI Techniques to Redefine Treatment Response in Patients With Glioblastoma.Journal of magnetic resonance imaging : JMRI · 2020Review
- Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness.Neuro-oncology · 2020Article
- Is there a prominent role for MR spectroscopy in the clinical management of brain tumors?Neuro-oncology · 2020Article
- High-resolution metabolic imaging of high-grade gliomas using 7T-CRT-FID-MRSI.NeuroImage. Clinical · 2020Article
- Article
- Three-dimensional echo planar spectroscopic imaging for differentiation of true progression from pseudoprogression in patients with glioblastoma.NMR in biomedicine · 2019Article
- Echo-planar spectroscopic imaging with dual-readout alternated gradients (DRAG-EPSI) at 7 T: Application for 2-hydroxyglutarate imaging in glioma patients.Magnetic resonance in medicine · 2018Article
- Measurement of glycine in healthy and tumorous brain by triple-refocusing MRS at 3 T in vivo.NMR in biomedicine · 2017Article
- In vivo (1)H MRSI of glycine in brain tumors at 3T.Magnetic resonance in medicine · 2016Article
- Distinguishing Myo-Inositol From Glycine in Brain MRS at 3T: A Pitfall Using Intermediate Echo Times.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
background and purposeIncreased glycine concentration in the brain is associated with altered metabolism in cancer and can be detected by using in vivo MR spectroscopy. This has been proposed as a marker for grade IV gliomas; however, little is known about the potential significance and frequency of in vivo glycine observation. The purpose of this study was to examine the rate of occurrence and spatial distribution of glycine observation with respect to other MR imaging parameters. MATERIALS AND
methodsData from volumetric whole-brain MR spectroscopic imaging of 59 subjects with glioma were analyzed with glycine included in the spectral model. The associations of the signal amplitude and spatial distributions of glycine with findings from contrast-enhanced T1, perfusion, and diffusion MR imaging were then examined.
resultsGlycine was detected in 24% of all studies, though with a wide range of signal amplitude and extent of the spatial distributions. While more commonly seen in grade IV tumors (42% of studies), relatively large concentrations were also detected in grade II and III gliomas. Coanalysis with other metabolites indicated a strong association with choline and that glycine was frequently seen to be overlapping with, and adjacent to, areas of high lactate concentration. Increased glycine was always associated with contrast enhancement and areas of increased cerebral blood flow, but without any clear association with other image parameters.
conclusionsDetection of increased glycine in gliomas appears to identify a subgroup of tumors and areas of increased proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.