ArticleProceedings of the National Academy of Sciences of the United States of America2014
PROTEIN DISULFIDE ISOMERASE LIKE 5-1 is a susceptibility factor to plant viruses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
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- Identification and characterization of a novel QTL for barley yellow mosaic disease resistance from bulbous barley.The plant genome · 2025Article
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- CRISPR-mediated genome editing of wheat for enhancing disease resistance.Frontiers in genome editing · 2025Review
- Study on molecular response of alfalfa to low temperature stress based on transcriptomic analysis.BMC plant biology · 2024Article
- Crop antiviral defense: Past and future perspective.Science China. Life sciences · 2024Review
- A novel QTL qRYM-7H for barley yellow mosaic resistance identified by GWAS and linkage analysis.Plant molecular biology · 2024Article
- Development and Characterization of a New TILLING Population for Forward and Reverse Genetics in Barley (Plants (Basel, Switzerland) · 2024Article
- ZmGDIα-hel counters the RBSDV-induced reduction of active gibberellins to alleviate maize rough dwarf virus disease.Nature communications · 2024Article
- Article
- Protein Disulfide Isomerase FgEps1 Is a Secreted Virulence Factor inJournal of fungi (Basel, Switzerland) · 2023Article
- Novel resistance to the Bymovirus BaMMV established by targeted mutagenesis of the PDIL5-1 susceptibility gene in barley.Plant biotechnology journal · 2023Article
- The sieve-element endoplasmic reticulum: A focal point of phytoplasma-host plant interaction?Frontiers in microbiology · 2023Article
- Two dominant genes in barley (Breeding science · 2022Article
- A reference-guided TILLING by amplicon-sequencing platform supports forward and reverse genetics in barley.Plant communications · 2022Article
- Review
- Extensive allele mining discovers novel genetic diversity in the loci controlling frost tolerance in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- High-Resolution Mapping ofFrontiers in plant science · 2022Article
- Mutation of barleyFrontiers in plant science · 2022Article
- Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Protein disulfide isomerases (PDIs) catalyze the correct folding of proteins and prevent the aggregation of unfolded or partially folded precursors. Whereas suppression of members of the PDI gene family can delay replication of several human and animal viruses (e.g., HIV), their role in interactions with plant viruses is largely unknown. Here, using a positional cloning strategy we identified variants of PROTEIN DISULFIDE ISOMERASE LIKE 5-1 (HvPDIL5-1) as the cause of naturally occurring resistance to multiple strains of Bymoviruses. The role of wild-type HvPDIL5-1 in conferring susceptibility was confirmed by targeting induced local lesions in genomes for induced mutant alleles, transgene-induced complementation, and allelism tests using different natural resistance alleles. The geographical distribution of natural genetic variants of HvPDIL5-1 revealed the origin of resistance conferring alleles in domesticated barley in Eastern Asia. Higher sequence diversity was correlated with areas with increased pathogen diversity suggesting adaptive selection for bymovirus resistance. HvPDIL5-1 homologs are highly conserved across species of the plant and animal kingdoms implying that orthologs of HvPDIL5-1 or other closely related members of the PDI gene family may be potential susceptibility factors to viruses in other eukaryotic species.
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