ArticleEvolution, medicine, and public health2013
Evolutionary biology and anthropology suggest biome reconstitution as a necessary approach toward dealing with immune disorders.
Article in Evolution, medicine, and public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Evolutionary Mismatch, Stress, and Competition: Making Sense of Psychosocial Problems in the Polycrisis Era.Behavioral sciences (Basel, Switzerland) · 2026Review
- Transcriptomic profiling reveals Trichinella spiralis-mediated attenuation of respiratory syncytial virus-induced inflammation in mice.Parasites, hosts and diseases · 2026Article
- Coevolutionary interplay: Helminths-trained immunity and its impact on the rise of inflammatory diseases.eLife · 2025Review
- Rethinking ADHD as a neurointestinal syndrome: a gut-brain-parasite hypothesis.Frontiers in neuroscience · 2025Article
- Reevaluating Biota Alteration: Reframing Environmental Influences on Chronic Immune Disorders and Exploring Novel Therapeutic Opportunities.The Yale journal of biology and medicine · 2024Review
- Cancer hygiene hypothesis: A test from wild captive mammals.Ecology and evolution · 2023Article
- COVID-19 morbidity in lower versus higher income populations underscores the need to restore lost biodiversity of eukaryotic symbionts.iScience · 2023Review
- Mitigation ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Evolution, the Immune System, and the Health Consequences of Socioeconomic Inequality.mSystems · 2022Article
- Multiple sclerosis and the microbiota: Progress in understanding the contribution of the gut microbiome to disease.Evolution, medicine, and public health · 2022Review
- Greater chronic morbidity is associated with greater fatigue in six countries: A case of evolutionary mismatch?Evolution, medicine, and public health · 2022Article
- Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect.Microorganisms · 2021Article
- Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes.Frontiers in microbiology · 2021Review
- The Hygiene Hypothesis - Learning From but Not Living in the Past.Frontiers in immunology · 2021Review
- Article
- Between a hygiene rock and a hygienic hard place: Avoiding SARS-CoV-2 while needing environmental exposures for immunity.Evolution, medicine, and public health · 2021Review
- GAS6 signaling tempers Th17 development in patients with multiple sclerosis and helminth infection.PLoS pathogens · 2020Article
- Contrasting Strategies: Human Eukaryotic Versus Bacterial Microbiome Research.The Journal of eukaryotic microbiology · 2020Review
- Review
- Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Industrialized society currently faces a wide range of non-infectious, immune-related pandemics. These pandemics include a variety of autoimmune, inflammatory and allergic diseases that are often associated with common environmental triggers and with genetic predisposition, but that do not occur in developing societies. In this review, we briefly present the idea that these pandemics are due to a limited number of evolutionary mismatches, the most damaging being 'biome depletion'. This particular mismatch involves the loss of species from the ecosystem of the human body, the human biome, many of which have traditionally been classified as parasites, although some may actually be commensal or even mutualistic. This view, evolved from the 'hygiene hypothesis', encompasses a broad ecological and evolutionary perspective that considers host-symbiont relations as plastic, changing through ecological space and evolutionary time. Fortunately, this perspective provides a blueprint, termed 'biome reconstitution', for disease treatment and especially for disease prevention. Biome reconstitution includes the controlled and population-wide reintroduction (i.e. domestication) of selected species that have been all but eradicated from the human biome in industrialized society and holds great promise for the elimination of pandemics of allergic, inflammatory and autoimmune diseases.
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