ArticleInternational journal of molecular sciences2014
Risk-association of five SNPs in TOX3/LOC643714 with breast cancer in southern China.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Association of three SNPs in TOX3 and breast cancer risk: Evidence from 97275 cases and 128686 controls.Scientific reports · 2015Pooled it
- Associations of Genetic Variants at Nongenic Susceptibility Loci with Breast Cancer Risk and Heterogeneity by Tumor Subtype in Southern Han Chinese Women.BioMed research international · 2016Trial
- Risk Association ofCurrent oncology (Toronto, Ont.) · 2022Article
- Article
- The association of CASC16 variants with breast Cancer risk in a northwest Chinese female population.Molecular medicine (Cambridge, Mass.) · 2020Article
- AnJournal of genetics · 2019Article
- Association ofEXCLI journal · 2019Article
- A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer.Carcinogenesis · 2018Article
- Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.International journal of molecular sciences · 2016Article
- Identification of novel susceptibility markers for the risk of overall breast cancer as well as subtypes defined by hormone receptor status in the Chinese population.Journal of human genetics · 2016Article
- The breast cancer susceptibility-related polymorphisms at the TOX3/LOC643714 locus associated with lung cancer risk in a Han Chinese population.Oncotarget · 2016Article
- TOX3 protein expression is correlated with pathological characteristics in breast cancer.Oncology letters · 2016Article
- Genetic polymorphisms in estrogen-related genes and the risk of breast cancer among Han Chinese women.International journal of molecular sciences · 2015Article
- Heterogeneity of Breast Cancer Associations with Common Genetic Variants in FGFR2 according to the Intrinsic Subtypes in Southern Han Chinese Women.BioMed research international · 2015Article
- TOX gene: a novel target for human cancer gene therapy.American journal of cancer research · 2015Review
- Comparing the value of mammographic features and genetic variants in breast cancer risk prediction.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2014Article
- Associations of two common genetic variants with breast cancer risk in a chinese population: a stratified interaction analysis.PloS one · 2014Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The specific mechanism by which low-risk genetic variants confer breast cancer risk is currently unclear, with contradictory evidence on the role of single nucleotide polymorphisms (SNPs) in TOX3/LOC643714 as a breast cancer susceptibility locus. Investigations of this locus using a Chinese population may indicate whether the findings initially identified in a European population are generalizable to other populations, and may provide new insight into the role of genetic variants in the etiology of breast cancer. In this case-control study, 623 Chinese female breast cancer patients and 620 cancer-free controls were recruited to investigate the role of five SNPs in TOX3/LOC643714 (rs8051542, rs12443621, rs3803662, rs4784227, and rs3112612); Linkage disequilibrium (LD) pattern analysis was performed. Additionally, we evaluated how these common SNPs influence the risk of specific types of breast cancer, as defined by estrogen receptor (ER) status, progesterone receptor (PR) status and human epidermal growth factor receptor 2 (HER2) status. Significant associations with breast cancer risk were observed for rs4784227 and rs8051542 with odds ratios (OR) of 1.31 ((95% confidence intervals (CI), 1.10-1.57)) and 1.26 (95% CI, 1.02-1.56), respectively, per T allele. The T-rs8051542 allele was significantly associated with ER-positive and HER2-negative carriers. No significant association existed between rs12443621, rs3803662, and rs3112612 polymorphisms and risk of breast cancer. Our results support the hypothesis that the applicability of a common susceptibility locus must be confirmed among genetically different populations, which may together explain an appreciable fraction of the genetic etiology of breast cancer.
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