ReviewCurrent opinion in organ transplantation2014
Ectopic transplantation sites for cell-based therapy.
Review in Current opinion in organ transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Creation of a rich vascular subcutaneous space for cell transplantation via injectable biological hydrogels.Scientific reports · 2025Article
- Standard Protocols for Characterising Primary and In Vitro-Generated Human Hepatocytes.Journal of cellular and molecular medicine · 2025Review
- Lung organoids: current strategies for generation and transplantation.Cell and tissue research · 2022Review
- Cell and Tissue Therapy for the Treatment of Chronic Liver Disease.Annual review of biomedical engineering · 2021Review
- Liver and Hepatocyte Transplantation: What Can Pigs Contribute?Frontiers in immunology · 2021Review
- Article
- Humanized Mouse Models for Evaluation of PSC Immunogenicity.Current protocols in stem cell biology · 2020Review
- Biliary Obstruction Promotes Multilineage Differentiation of Hepatic Stem Cells.Hepatology communications · 2019Article
- Characterization, recellularization, and transplantation of rat decellularized testis scaffold with bone marrow-derived mesenchymal stem cells.Stem cell research & therapy · 2018Article
- Transplantation of hepatocytes from genetically engineered pigs into baboons.Xenotransplantation · 2017Article
- Regenerating a kidney in a lymph node.Pediatric nephrology (Berlin, Germany) · 2016Review
- Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement.Transplantation · 2016Article
- The lymph node as a new site for kidney organogenesis.Stem cells translational medicine · 2015Article
- Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery.Current opinion in chemical engineering · 2015Article
- Cellular homeostasis and repair in the mammalian liver.Annual review of physiology · 2015Review
- Underpinnings of cellular organ replacement therapies.Current opinion in organ transplantation · 2014Article
- Maturation of embryonic tissues in a lymph node: a new approach for bioengineering complex organs.Organogenesis · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewThis review outlines the concept of cell-based therapy to restore tissue function, and addresses four key points to consider in cell transplantation: source, surveillance, safety, and site. Whereas each point is essential, additional attention should be given to transplantation sites if cell therapy is going to be successful in the clinic. Various ectopic locations are discussed, and the strengths and weaknesses of each are compared as suitable candidates for cell therapy. RECENT
findingsStudies in rodents often demonstrate cell transplantation and engraftment in ectopic sites, with little evidence to suggest why it may also work in humans. For example, transplantation to the subcapsular space of the kidney is often performed in rodents, but has not been a good predictor of clinical success. Recent work has shown that the lymph node may be a good site for transplantation of multiple tissue types, and several reasons are highlighted as to why it should be considered for future studies. SUMMARY: The use of cell-based therapy in the clinic has been hampered by the lack of appropriate sites for transplantation. The lymph node is a promising alternative for cell transplantation, and offers hope for clinical application.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.