ReviewIntegrative biology : quantitative biosciences from nano to macro2014
Unraveling intestinal stem cell behavior with models of crypt dynamics.
Review in Integrative biology : quantitative biosciences from nano to macro, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Dedifferentiation-driven oncogenic stemness promotes tumor-sustaining adaptability in the intestinal epithelium.Cell death & disease · 2026Article
- Fast interrogation of intestinal organ-on-chip devices through inverted single-plane illumination microscopy (iSPIM) using an electro-tunable lens.Biomedical optics express · 2025Article
- Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance.Development (Cambridge, England) · 2025Article
- Stochastic model for cell population dynamics quantifies homeostasis in colonic crypts and its disruption in early tumorigenesis.Proceedings. Biological sciences · 2023Article
- Characterization of Early and Late Damage in a Mouse Model of Pelvic Radiation Disease.International journal of molecular sciences · 2023Article
- Mathematical modelling identifies conditions for maintaining and escaping feedback control in the intestinal epithelium.Scientific reports · 2022Article
- Nutritional stimulation by in-ovo feeding modulates cellular proliferation and differentiation in the small intestinal epithelium of chicks.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia-reperfusion injuryFrontiers in cell and developmental biology · 2022Article
- NF-κB determines Paneth versus goblet cell fate decision in the small intestine.Development (Cambridge, England) · 2021Article
- NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation.Cell reports · 2021Article
- Surface Modification of Polycaprolactone Scaffold With Improved Biocompatibility and Controlled Growth Factor Release for Enhanced Stem Cell Differentiation.Frontiers in bioengineering and biotechnology · 2021Article
- Article
- Cytoskeletal Control and Wnt Signaling-APC's Dual Contributions in Stem Cell Division and Colorectal Cancer.Cancers · 2020Review
- Changes with age in density of goblet cells in the small intestine of broiler chicks.Poultry science · 2020Article
- It's All About Timing: Early Feeding Promotes Intestinal Maturation by Shifting the Ratios of Specialized Epithelial Cells in Chicks.Frontiers in physiology · 2020Article
- Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Asymmetric cell division-dominant neutral drift model for normal intestinal stem cell homeostasis.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Unraveling the Control of Cell Cycle Periods during Intestinal Stem Cell Differentiation.Biophysical journal · 2018Article
- Dietary Lipids Modulate Notch Signaling and Influence Adult Intestinal Development and Metabolism in Drosophila.Developmental cell · 2018Article
- Quantitative translational modeling to facilitate preclinical to clinical efficacy & toxicity translation in oncology.Future science OA · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The definition, regulation and function of intestinal stem cells (ISCs) has been hotly debated. Recent discoveries have started to clarify the nature of ISCs, but many questions remain. This review discusses the current advances and controversies of ISC biology as well as theoretical compartmental models that have been coupled with in vivo experimentation to investigate the mechanisms of ISC dynamics during homeostasis, tumorigenesis, repair and development. We conclude our review by discussing the key lingering questions in the field and proposing how many of these questions can be addressed using both compartmental models and experimental techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.