Cyclin C: an inducer of mitochondrial division hidden in the nucleus.

Yoshihiro Adachi, Hiromi Sesaki

Open access · bronzeAbstract readComment

In one paragraph

Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.3field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

Cyclin C mediates stress-induced mitochondrial fission and apoptosis.Molecular biology of the cell · 2015
Article
Slt2p phosphorylation induces cyclin C nuclear-to-cytoplasmic translocation in response to oxidative stress.Molecular biology of the cell · 2014
Article

4 · The record

Corrections and comments

Comment on
Stress-induced nuclear-to-cytoplasmic translocation of cyclin C promotes mitochondrial fission in yeast.2014

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yoshihiro AdachiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Hiromi SesakiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: hsesaki@jhmi.edu.

Johns Hopkins University · US

Funding

Mitochondrial Fusion and DivisionR01GM089853 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2010 to 2014

$2.1M

Introducing Mitochondrial Stasis in NeuronsR21NS084154 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2013 to 2014

$443k

NIGMS NIH HHS R01 GM089853NINDS NIH HHS R21 NS084154

6 · The paper itself

Abstract

In response to cellular stress, mitochondria remodel their structure by organelle division and fusion. In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of the cell.

Indexed as

Mitochondrial DynamicsOxidative StressCell NucleusCyclin-Dependent Kinase 8Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCyclin-Dependent Kinase 8Saccharomyces cerevisiae ProteinsSSN3 protein, S cerevisiae

Identifiers

PMID24480640

DOI10.1016/j.devcel.2014.01.010

PMCPMC3971902

OpenAlexW1973366123

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.