Trial reportGastroenterology2014
Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women.
Trial report in Gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- GLP-1 Analog Modulates Appetite, Taste Preference, Gut Hormones, and Regional Body Fat Stores in Adults with Obesity.The Journal of clinical endocrinology and metabolism · 2020Trial
- Trial
- Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake.International journal of obesity (2005) · 2016Trial
- Resting-State fMRI Reveals the Neural Correlates of Acupuncture in the Treatment of Vascular Cognitive Impairment.Clinical interventions in aging · 2025Review
- CD8 cytotoxic T-cell infiltrates and cellular damage in the hypothalamus in human obesity.Acta neuropathologica communications · 2023Article
- Machine learning model to predict obesity using gut metabolite and brain microstructure data.Scientific reports · 2023Article
- The effect of hunger state on hypothalamic functional connectivity in response to food cues.Human brain mapping · 2023Article
- Trigeminal Stimulus Menthol Masks Bitter Off-Flavor of Artificial Sweetener Acesulfame-K.Foods (Basel, Switzerland) · 2022Article
- Regional brain dysfunction in insomnia after ischemic stroke: A resting-state fMRI study.Frontiers in neurology · 2022Article
- Neural network modelling reveals changes in directional connectivity between cortical and hypothalamic regions with increased BMI.International journal of obesity (2005) · 2021Article
- The Microbiota and the Gut-Brain Axis in Controlling Food Intake and Energy Homeostasis.International journal of molecular sciences · 2021Review
- Brain-gut-microbiome interactions in obesity and food addiction.Nature reviews. Gastroenterology & hepatology · 2020Review
- Host-microbiome interactions: the aryl hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling.Gut microbes · 2020Review
- The Effect of Food Composition and Behavior on Neurobiological Response to Food: a Review of Recent Research.Current nutrition reports · 2020Review
- The interrelationship of body mass index with gray matter volume and resting-state functional connectivity of the hypothalamus.International journal of obesity (2005) · 2020Article
- History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity.Obesity science & practice · 2019Article
- A paradigm shift for the prevention and treatment of individual and global obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2018Article
- Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects.PloS one · 2018Article
- The effect of the GLP-1 analogue Exenatide on functional connectivity within an NTS-based network in women with and without obesity.Obesity science & practice · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsThe study of intrinsic fluctuations in the blood oxygen level-dependent signal of functional magnetic resonance imaging can provide insight into the effect of physiologic states on brain processes. In an effort to better understand the brain-gut communication induced by the absorption and metabolism of nutrients in healthy lean and obese individuals, we investigated whether ingestion of nutritive and non-nutritive sweetened beverages differentially engages the hypothalamus and brainstem vagal pathways in lean and obese women.
methodsIn a 2-day, double-blind crossover study, 11 lean and 11 obese healthy women underwent functional magnetic resonance imaging scans after ingestion of 2 beverages of different sucrose content, but identical sweetness. During scans, subjects rested with eyes closed.
resultsBlood oxygen level-dependent fluctuations demonstrated significantly greater power in the highest frequency band (slow-3: 0.073-0.198 Hz) after ingestion of high-sucrose compared with low-sucrose beverages in the nucleus tractus solitarius for both groups. Obese women had greater connectivity between the right lateral hypothalamus and a reward-related brain region and weaker connectivity with homeostasis and gustatory-related brain regions than lean women.
conclusionsIn a functional magnetic resonance imaging study, we observed sucrose-related changes in oscillatory dynamics of blood oxygen level-dependent fluctuations in brainstem and hypothalamus in lean and obese women. The observed frequency changes are consistent with a rapid vagally mediated mechanism due to nutrient absorption, rather than sweet taste receptor activation. These findings provide support for altered interaction between homeostatic and reward networks in obese individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.