Trial reportEarly human development2014
Effect of holding on co-regulation in preterm infants: a randomized controlled trial.
Trial report in Early human development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06096961 (The Effect Of Baby Smell On The Amount Of Breast Milk, Salivary Cortisol Level And Mother Baby Attachment), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect Of Baby Smell On The Amount Of Breast Milk, Salivary Cortisol Level And Mother Baby Attachment: A Randomized Controlled Study
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- First Brazilian recommendation on physiotherapy with sensory motor stimulation in newborns and infants in the intensive care unit.Revista Brasileira de terapia intensivaPooled it
- Effects of Kangaroo care during retinopathy screening examination: a randomised clinical trial.BMJ paediatrics open · 2026Trial
- Effect of zero-separation in mother-newborn care unit on preterm infant's stress and growth.The Indian journal of medical research · 2026Article
- Benefits of Kangaroo Mother Care on the Physiological Stress Parameters of Preterm Infants and Mothers in Neonatal Intensive Care.International journal of environmental research and public health · 2022Article
- Assessment and Correction of Stress in Preterm Infants and Their Mothers.Turkish archives of pediatrics · 2022Article
- Skin-to-Skin Care is Associated with Reduced Stress, Anxiety, and Salivary Cortisol and Improved Attachment for Mothers of Infants With Critical Congenital Heart Disease.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2021Article
- Skin-to-Skin Care Is a Safe and Effective Comfort Measure for Infants Before and After Neonatal Cardiac Surgery.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020Article
- Mothering in the NICU: A qualitative exploration of maternal engagement.Social work in health care · 2019Article
- An integrative review: maternal engagement in the neonatal intensive care unit and health outcomes for U.S.-born preterm infants and their parents.AIMS public health · 2019Review
- Article
- Salivary Cortisol Reactivity in Preterm Infants in Neonatal Intensive Care: An Integrative Review.International journal of environmental research and public health · 2016Review
- Psychometric Properties of the Parent-Infant Caregiving Touch Scale.Frontiers in psychology · 2015Article
- A Case Study of Infant Physiologic Response to Skin-to-Skin Contact After Surgery for Complex Congenital Heart Disease.The Journal of cardiovascular nursingArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo determine whether kangaroo holding of healthy preterm infants over the first eight weeks of an infant's life facilitates co-regulation of salivary cortisol between mother and infant. STUDY
designRandomized control trial. Infants were assigned to receive 1h of daily kangaroo (skin-to-skin contact on the chest of mother) or blanket holding (dressed and held in mother's arms). A registered nurse visited mothers weekly for eight weeks to encourage holding and provide information about infant development. A control group had no holding restrictions and received weekly brief social visits. SUBJECTS: The study included 79 preterm infants, born between 32 and 35weeks gestational age and were a mean of 15days (±5.7) at enrollment. OUTCOME MEASURES: Co-regulation was conceptualized as progressive reduction in the absolute difference between mother and infant cortisol levels across 60min of holding at each holding session. Mother and infant cortisol levels were measured before holding and at 30 and 60min after holding began during three holding sessions (baseline and at two and eight weeks after study initiation). Primary analyses were conducted using hierarchical linear models.
resultsThere was much variability in cortisol levels. Levels of mother and infant cortisol decreased during holding. No significant co-regulation occurred in any group at any holding session or over time.
conclusionsDecreasing level of cortisol in both mothers and infants suggests that holding promoted the expected decline in stress hormone levels. However, supported holding methods did not differentially affect co-regulation compared to controls. Holding is pleasurable and stress may need to be present in order for mothers and infants to demonstrate co-regulation in cortisol levels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.