ArticleMethods in enzymology2014
Isolation and quantitation of adiponectin higher order complexes.
Article in Methods in enzymology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Visceral Adiposity and Renal Health: From Pathophysiological Mechanisms to Novel Therapeutic Strategies.Journal of clinical medicine · 2026Review
- Human Adipose Allograft Restores Volume Through Host-mediated Tissue Replacement.Plastic and reconstructive surgery. Global open · 2026Article
- Evaluation of an Immunoturbidometric Assay for Measurement of Total Adiponectin Concentration in Equine Serum Samples.Veterinary clinical pathology · 2026Article
- Association of serum adiponectin level with glycemic control and atherogenic lipid profile in Sudanese patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Alterations in infant adipokine concentrations in the first postnatal week with exposure to diabetes in pregnancy.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Adiponectin and Glucocorticoids Modulate Risk for Preterm Birth: The Healthy Start Study.The Journal of clinical endocrinology and metabolism · 2025Article
- When a Calorie Is Not a Calorie: Metabolic and Molecular Effects of Intermittent Fasting in Humans; Exploratory Outcomes of a Randomized Clinical Trial.Aging biology · 2023Article
- The Complex Interactions Between Obesity, Metabolism and the Brain.Frontiers in neuroscience · 2019Review
- Adiponectin Isoform Patterns in Ethnic-Specific ADIPOQ Mutation Carriers: The IRAS Family Study.Obesity (Silver Spring, Md.) · 2017Article
- Adiponectin, Insulin Sensitivity, β-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY.Diabetes care · 2017 · on this mapArticle
- Feeding a Modified Fish Diet to Bottlenose Dolphins Leads to an Increase in Serum Adiponectin and Sphingolipids.Frontiers in endocrinology · 2016Article
- Adiponectin isoforms differentially affect gene expression and the lipidome of primary human hepatocytes.Metabolites · 2014Article
- Differential transendothelial transport of adiponectin complexes.Cardiovascular diabetology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Adiponectin is a circulating bioactive hormone secreted by adipocytes as oligomers ranging in size from 90 kDa trimers and 180 kDa hexamers to larger high molecular weight oligomers that may reach 18- or 36-mers in size. While total circulating adiponectin levels correlate well with metabolic health, it is the relative distribution of adiponectin complexes that is most clinically relevant to glucose sensitivity and inflammation. High molecular weight adiponectin best mirrors insulin sensitivity, while trimeric adiponectin dominates with insulin resistance and adipose tissue inflammation. Experimental animal and in vitro models have also linked the relative fraction of high molecular weight adiponectin to its positive effects. Quantitating adiponectin size distribution thus provides a window into metabolic health and can serve as a surrogate marker for adipose tissue fitness. Here, we present a detailed protocol for isolating and quantitating adiponectin complexes in serum or plasma that has been extensively utilized for both human clinical samples and numerous animal models under various experimental conditions. Examples are presented of different adiponectin distributions and tips are provided for optimization using available equipment. Comparison of this rigorous approach to other available methods is also discussed. In total, this summary is a blueprint for the expanded quantitation and study of adiponectin complexes.
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