ArticleEpidemiology and infection2014
Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection.
Article in Epidemiology and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Plasma metabolomics in infancy reveals early signatures of a stringently-defined otitis-prone phenotype.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Systems perspectives on pediatric otitis media: environmental exposures, genetic susceptibility, and biomarker-guided interventions.Frontiers in pediatrics · 2026Review
- Variability in Vaccine Response and Trajectory in Early Childhood and Association With Demographic Variables, Antibiotic Exposure, and Infection Proneness.The Journal of infectious diseases · 2025Article
- Pneumococci Isolated From Children in Community-Based Practice Differ From Isolates Identified by Population- and Laboratory-Based Invasive Disease Surveillance.The Journal of infectious diseases · 2024Article
- Three Innate Cytokine Biomarkers Predict Presence of Acute Otitis Media and Relevant Otopathogens.Biomarkers and applications · 2018Article
- Article
- Reduced T-Helper 17 Responses to Streptococcus pneumoniae in Infection-Prone Children Can Be Rescued by Addition of Innate Cytokines.The Journal of infectious diseases · 2017Article
- Kinetics of antibodies against pneumococcal proteins and their relationship to nasopharyngeal carriage in the first two months of life.PloS one · 2017Article
- Differences in innate immune response gene regulation in the middle ear of children who are otitis prone and in those not otitis prone.American journal of rhinology & allergy · 2016Article
- Inflammation-associated cytokine analysis identifies presence of respiratory bacterial pathogens in the nasopharynx.Pathogens and disease · 2016Article
- Emerging Streptococcus pneumoniae Strains Colonizing the Nasopharynx in Children After 13-valent Pneumococcal Conjugate Vaccination in Comparison to the 7-valent Era, 2006-2015.The Pediatric infectious disease journal · 2016Article
- Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants.The Journal of infectious diseases · 2016Article
- The role of respiratory viruses in the etiology of bacterial pneumonia: An ecological perspective.Evolution, medicine, and public health · 2016Review
- Next generation protein based Streptococcus pneumoniae vaccines.Human vaccines & immunotherapeutics · 2016Review
- Familial and microbiological contribution to the otitis-prone condition.International journal of pediatric otorhinolaryngology · 2015Article
- Cytokine, chemokine, and Toll-like receptor expression in middle ear fluids of children with acute otitis media.The Laryngoscope · 2015Article
- Correlation of nasopharyngeal cultures prior to and at onset of acute otitis media with middle ear fluid cultures.BMC infectious diseases · 2014Article
- The host immune dynamics of pneumococcal colonization: implications for novel vaccine development.Human vaccines & immunotherapeutics · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
During a 5-year prospective study of nasopharyngeal (NP) colonization and acute otitis media (AOM) infections in children during the 7-valent pneumococcal conjugate vaccine (PCV) era (July 2006-June 2011) we studied risk factors for NP colonization and AOM. NP samples were collected at ages 6, 9, 12, 15, 18, 24, and 30 months during well-child visits. Additionally, NP and middle ear fluid (MEF) samples were collected at onset of every AOM episode. From 1825 visits (n = 464 children), 5301 NP and 570 MEF samples were collected and analysed for potential otopathogens. Daycare attendance, NP colonization by Moraxella catarrhalis, and siblings aged <5 years increased the risk of Streptococcus pneumoniae NP colonization. NP colonization with S. pneumoniae, M. catarrhalis, or Haemophilus influenzae and a family history of OM increased the risk of AOM. Risk factors that increase the risk of pneumococcal AOM will be important to reassess as we move into a new 13-valent PCV era, especially co-colonization with other potential otopathogens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.