ArticleBiophysical journal1987
Diffusion of dihydropyridine calcium channel antagonists in cardiac sarcolemmal lipid multibilayers.
Article in Biophysical journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 80 citations in OpenAlex.
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- Physiological significance of delayed rectifier K(+) channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease.The journal of physiological sciences : JPS · 2015Review
- Ligands, their receptors and ... plasma membranes.Molecular and cellular endocrinology · 2009Review
- Molecular mechanisms for the persistent bronchodilatory effect of the beta 2-adrenoceptor agonist salmeterol.British journal of pharmacology · 2009Article
- Synergistic effect of amlodipine and atorvastatin in reversing LDL-induced endothelial dysfunction.Pharmaceutical research · 2008Article
- Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction.Biophysical journal · 2003Article
- Locating phospholamban in co-crystals with Ca(2+)-ATPase by cryoelectron microscopy.Biophysical journal · 2001Article
- How to make tubular crystals by reconstitution of detergent-solubilized Ca2(+)-ATPase.Biophysical journal · 1997Article
- Na+ current and Ca2+ release from the sarcoplasmic reticulum during action potentials in guinea-pig ventricular myocytes.The Journal of physiology · 1995Article
- Attenuation of channel kinetics and conductance by cholesterol: an interpretation using structural stress as a unifying concept.The Journal of membrane biology · 1995Article
- Interaction of the NMDA receptor noncompetitive antagonist MK-801 with model and native membranes.Biophysical journal · 1994Article
- Molecular basis for the inhibition of 1,4-dihydropyridine calcium channel drugs binding to their receptors by a nonspecific site interaction mechanism.Biophysical journal · 1992Article
- Bilayer structure and physical dynamics of the cytochrome b5 dimyristoylphosphatidylcholine interaction.Biophysical journal · 1992Article
- Hydrophobic properties of novel dihydronaphthyridine calcium antagonists and biological activity in porcine isolated cardiac and vascular smooth muscle.Naunyn-Schmiedeberg's archives of pharmacology · 1991Article
- Review
- Rat cerebral cortical synaptoneurosomal membranes. Structure and interactions with imidazobenzodiazepine and 1,4-dihydropyridine calcium channel drugs.Biophysical journal · 1990Article
- Diffusional dynamics of an active rhodamine-labeled 1,4-dihydropyridine in sarcolemmal lipid multibilayers.Biophysical journal · 1989Article
- Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor.The Journal of general physiology · 1989Article
- Partitioning and location of Bay K 8644, 1,4-dihydropyridine calcium channel agonist, in model and biological membranes.Biophysical journal · 1989Article
- Structure and location of amiodarone in a membrane bilayer as determined by molecular mechanics and quantitative x-ray diffraction.Biophysical journal · 1988Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
A membrane bilayer pathway model has been proposed for the interaction of dihydropyridine (DHP) calcium channel antagonists with receptors in cardiac sarcolemma (Rhodes, D.G., J.G. Sarmiento, and L.G. Herbette. 1985. Mol. Pharmacol. 27:612-623) involving drug partition into the bilayer with subsequent receptor binding mediated (though probably not rate-limited) by diffusion within the bilayer. Recently, we have characterized the partition step, demonstrating that DHPs reside, on a time-average basis, near the bilayer hydrocarbon core/water interface. Drug distribution about this interface may define a plane of local concentration for lateral diffusion within the membrane. The studies presented herein examine the diffusional dynamics of an active rhodamine-labeled DHP and a fluorescent phospholipid analogue (DiIC16) in pure cardiac sarcolemmal lipid multibilayer preparations as a function of bilayer hydration. At maximal bilayer hydration, the drug diffuses over macroscopic distances within the bilayer at a rate identical to that of DiI (D = 3.8 X 10(-8) cm2/s), demonstrating the overall feasibility of the membrane diffusion model. The diffusion coefficients for both drug and lipid decreased substantially as the bilayers were dehydrated. While identical at maximal hydration, drug diffusion was significantly slower than that of DiIC16 in partially dehydrated bilayers, probably reflecting differences in mass distribution of these probes in the bilayer.
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