Evidence map›Paper›PMID 24479111›Full record

ReviewFrontiers in pediatrics2014

Fecal biomarkers of intestinal health and disease in children.

Tamara Pang, Steven T Leach, Tamarah Katz, Andrew S Day, Chee Y Ooi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Intestinal and fecal pH in human health.Frontiers in microbiomes · 2023
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tamara PangFaculty of Medicine, School of Women's and Children's Health, University of New South Wales , Sydney, NSW , Australia.
Steven T LeachFaculty of Medicine, School of Women's and Children's Health, University of New South Wales , Sydney, NSW , Australia ; Department of Gastroenterology, Sydney Children's Hospital Randwick , Sydney, NSW , Australia.
Tamarah KatzDepartment of Nutrition and Dietetics, Sydney Children's Hospital , Sydney, NSW , Australia.
Andrew S DayDepartment of Paediatrics, University of Otago , Christchurch , New Zealand.
Chee Y OoiFaculty of Medicine, School of Women's and Children's Health, University of New South Wales , Sydney, NSW , Australia ; Department of Gastroenterology, Sydney Children's Hospital Randwick , Sydney, NSW , Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The identification of various fecal biomarkers has provided insight into the intestinal milieu. Most of these markers are associated with the innate immune system of the gut, apart from the more novel M2-pyruvate kinase. The innate immunity of the gut plays a role in maintaining a fine balance between tolerance to commensal bacteria and immune response to potential pathogens. It is a complex system, which comprises of multiple elements, including antimicrobial peptides (e.g., defensins, cathelicidins, lactoferrin, and osteoprotegerin), inflammatory proteins (e.g., calprotectin and S100A12), and microbial products (e.g., short-chain fatty acids). Dysfunction of any component can lead to the development of intestinal disease, and different diseases have been associated with different fecal levels of these biomarkers. Each fecal biomarker provides information on specific biological and disease processes. Therefore, stool quantification of these biomarkers provides a non-invasive method to define potential pathways behind the pathogenesis of diseases and can assist in the assessment and diagnosis of various gastrointestinal conditions. The abovementioned fecal biomarkers and their role in intestinal health and disease will be reviewed in this paper with a pediatric focus.

Indexed as

calprotectincathelicidinsdefensinsinflammationlactoferrinM2-pyruvate kinaseosteoprotegerinS100A12

Identifiers

PMID24479111
PMCPMC3904282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.