Evidence map›Paper›PMID 24479108›Full record

ArticleFrontiers in pediatrics2014

Non-Specific Gastric Inflammation in Children is Associated with Proton Pump Inhibitor Treatment for More than 6 Weeks.

Eduardo Rosas-Blum, Nina Tatevian, Syed Shahrukh Hashmi, Jon Marc Rhoads, Fernando Navarro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Natural Progression of Helicobacter pylori-Negative Gastritis with Lymphoid Follicles in Children: Prospective Evaluation and Outcome.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021
    Article
  2. Article
  3. Lymphoid follicles in children withClinical and experimental gastroenterology · 2017
    Article
  4. Rising Prevalence of Mild Chronic Gastritis in Children: A Single Center Experience.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eduardo Rosas-BlumDivision of Pediatric Gastroenterology, Department of Pediatrics, Texas Tech University Health Sciences Center , El Paso, TX , USA.
Nina TatevianDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center , Houston, TX , USA.
Syed Shahrukh HashmiDivision of Pediatric Gastroenterology, Department of Pediatrics, University of Texas Health Science Center , Houston, TX , USA.
Jon Marc RhoadsDivision of Pediatric Gastroenterology, Department of Pediatrics, University of Texas Health Science Center , Houston, TX , USA ; Division of Pediatric Gastroenterology, Department of Pediatrics, Children's Memorial Hermann Hospital , Houston, TX , USA.
Fernando NavarroDivision of Pediatric Gastroenterology, Department of Pediatrics, University of Texas Health Science Center , Houston, TX , USA ; Division of Pediatric Gastroenterology, Department of Pediatrics, Children's Memorial Hermann Hospital , Houston, TX , USA.
The University of Texas Health Science Center at Houston · USTexas Tech University Health Sciences Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsNon-specific gastric inflammation (NSGI) is a commonly reported pathological finding. We investigated if it is associated with the use of proton pump inhibitors (PPIs) in children at a single tertiary center.

methodsWe performed an IRB-approved chart review of all endoscopy and biopsy reports of patients who underwent esophagogastroduodenoscopy between July 2009 and July 2010 (n = 310). Demographic data, dose, duration of exposure to PPI, and biopsy results were collected and analyzed. All esophageal, gastric, and duodenal biopsies were independently reviewed by a pathologist. Patients with acute gastritis, moderate/severe chronic gastric inflammation, or Helicobacter pylori infection were excluded. The presence of NSGI was compared between patients exposed and not exposed to PPI as well as between patients with different doses and durations of PPI exposure to assess for potential associations.

resultsA total of 193 patients were included: 88 (46%) had a history of PPI use and 48 (25%) were found to have NSGI. Compared to patients not exposed to PPI, the odds ratio of NSGI in patients exposed to PPIs was 2.81 (95% CI: 1.36-5.93). The odds ratio of NSGI in patients exposed to PPI for >3 months was 4.53 (95% CI: 1.69-11.97). Gender, ethnicity, and age were not associated with NSGI. No histological differences were found in the esophagus and duodenum between patients exposed and not exposed to PPI.

conclusionThis study found that PPI exposure is associated with NSGI with a higher risk for those exposed for >3 months. As the clinical implications of NSGI are not known, judicious use of PPIs is needed. Prospective studies are required to confirm and to determine the etiologic factors (i.e., alteration of the gastric pH, serum gastrin) that may be related with the presence of NGSI.

Indexed as

duodenal inflammationgastric biopsiesgastric inflammationpediatrics

Identifiers

PMID24479108
PMCPMC3895915
OpenAlexW2098090569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.