ArticleFrontiers in cellular and infection microbiology2014
Transcriptome analysis of Vibrio parahaemolyticus in type III secretion system 1 inducing conditions.
Article in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 284 citations in OpenAlex.
- Pathogen hijacks focal adhesion signaling by a T3SS effector CteX.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- T3SS protein EsrC binds to theApplied and environmental microbiology · 2024Article
- Transcriptome Analysis Reveals the Effect of Low NaCl Concentration on Osmotic Stress and Type III Secretion System inInternational journal of molecular sciences · 2023Article
- Gene Regulatory Network of the Noncoding RNAMicroorganisms · 2022Article
- Comparative transcriptomic analysis provides insights into transcription mechanisms of Vibrio parahaemolyticus T3SS during interaction with HeLa cells.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Article
- Conservation of Small Regulatory RNAs inInternational journal of molecular sciences · 2019Article
- Cold Tolerance Regulated by the Pyruvate Metabolism inFrontiers in microbiology · 2019Article
- Exploring the Genomic Traits of Non-toxigenicFrontiers in microbiology · 2018Article
- The Vibrio alginolyticus T3SS effectors, Val1686 and Val1680, induce cell rounding, apoptosis and lysis of fish epithelial cells.Virulence · 2018Article
- Article
- ExsE Is a Negative Regulator for T3SS Gene Expression inFrontiers in cellular and infection microbiology · 2016Article
- DNA-Binding Protein HU Coordinates Pathogenicity in Vibrio parahaemolyticus.Journal of bacteriology · 2015Article
- Transcriptomic Analysis of Yersinia enterocolitica Biovar 1B Infecting Murine Macrophages Reveals New Mechanisms of Extracellular and Intracellular Survival.Infection and immunity · 2015Article
- Transcriptional profiling of Vibrio parahaemolyticus exsA reveals a complex activation network for type III secretion.Frontiers in microbiology · 2015Article
- Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence.FEMS microbiology letters · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vibrio parahaemolyticus is an emerging bacterial pathogen capable of causing inflammatory gastroenteritis, wound infections, and septicemia. As a food-borne illness, infection is most frequently associated with the consumption of raw or undercooked seafood, particularly shellfish. It is the primary cause of Vibrio-associated food-borne illness in the United States and the leading cause of food-borne illness in Japan. The larger of its two chromosomes harbors a set of genes encoding type III section system 1 (T3SS1), a virulence factor present in all V. parahaemolyticus strains that is similar to the Yersinia ysc T3SS. T3SS1 translocates effector proteins into eukaryotic cells where they induce changes to cellular physiology and modulate host-pathogen interactions. T3SS1 is also responsible for cytotoxicity toward several different cultured cell lines as well as mortality in a mouse model. Herein we used RNA-seq to obtain global transcriptome patterns of V. parahaemolyticus under conditions that either induce [growth in Dulbecco's Modified Eagle Medium (DMEM) media, in trans expression of transcriptional regulator exsA] or repress T3SS1 expression (growth in LB-S media, in trans exsD expression) and during infection of HeLa cells over time. Comparative transcriptomic analysis demonstrated notable differences in the expression patterns under inducing conditions and was also used to generate an expression profile of V. parahaemolyticus during infection of HeLa cells. In addition, we identified several new genes that are associated with T3SS1 expression and may warrant further study.
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