ArticleEvolutionary applications2013
Dynamics of growth factor production in monolayers of cancer cells and evolution of resistance to anticancer therapies.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Fraternal cooperation of hierarchical cancer parallels metazoan multicellularity and eusociality.Biological reviews of the Cambridge Philosophical Society · 2026Review
- The depth of tumor hierarchy and its impact on hypertumor susceptibility.Scientific reports · 2025Article
- Sociobiology meets oncology: unraveling altruistic cooperation in cancer cells and its implications.Experimental & molecular medicine · 2025Review
- Frequency-dependent returns in nonlinear public goods games.Journal of the Royal Society, Interface · 2024Article
- Spatial simulation of autologous cell defection for cancer treatment.Evolution, medicine, and public health · 2023Article
- The role of evolutionary game theory in spatial and non-spatial models of the survival of cooperation in cancer: a review.Journal of the Royal Society, Interface · 2022Review
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- Nodes with the highest control power play an important role at the final level of cooperation in directed networks.Scientific reports · 2021Article
- Two-dimensional adaptive dynamics of evolutionary public goods games: finite-size effects on fixation probability and branching time.Royal Society open science · 2021Article
- Mimicking growth factors: role of small molecule scaffold additives in promoting tissue regeneration and repair.RSC advances · 2019Review
- Evolution of cooperation in an epithelium.Journal of the Royal Society, Interface · 2019Article
- Cooperation among cancer cells: applying game theory to cancer.Nature reviews. Cancer · 2019Review
- Share, but unequally: a plausible mechanism for emergence and maintenance of intratumour heterogeneity.Journal of the Royal Society, Interface · 2019Article
- Neighborhood size-effects shape growing population dynamics in evolutionary public goods games.Communications biology · 2019Article
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- Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect.Cell proliferation · 2015Article
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Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor heterogeneity is well documented for many characters, including the production of growth factors, which improve tumor proliferation and promote resistance against apoptosis and against immune reaction. What maintains heterogeneity remains an open question that has implications for diagnosis and treatment. While it has been suggested that therapies targeting growth factors are robust against evolved resistance, current therapies against growth factors, like antiangiogenic drugs, are not effective in the long term, as resistant mutants can evolve and lead to relapse. We use evolutionary game theory to study the dynamics of the production of growth factors by monolayers of cancer cells and to understand the effect of therapies that target growth factors. The dynamics depend on the production cost of the growth factor, on its diffusion range and on the type of benefit it confers to the cells. Stable heterogeneity is a typical outcome of the dynamics, while a pure equilibrium of nonproducer cells is possible under certain conditions. Such pure equilibrium can be the goal of new anticancer therapies. We show that current therapies, instead, can be effective only if growth factors are almost completely eliminated and if the reduction is almost immediate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.