ReviewFrontiers in immunology2014
The role of natural cytotoxicity receptors in various pathologies: emphasis on type I diabetes.
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship of immune cells with autism spectrum disorder: a bidirectional Mendelian randomization study.BMC psychiatry · 2024Pooled it
- Changes of macrophage and CD4Scientific reports · 2022Article
- Repurposing of existing antibiotics for the treatment of diabetes mellitus.In silico pharmacology · 2022Article
- Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes-Focus on Toll-like Receptors Expression.International journal of molecular sciences · 2021Article
- Low-dose interleukin-2-loaded nanoparticle effect on NK and T-reg cell expression in experimentally induced type 1 diabetes mellitus.Przeglad gastroenterologiczny · 2021Article
- The role of NK cells in fighting the virus infection and sepsis.International journal of medical sciences · 2021Review
- Effect of low dose IL-2 loaded chitosan nanoparticles on natural killer and regulatory T cell expression in experimentally induced autoimmune type 1 diabetes mellitus.Central-European journal of immunology · 2020Article
- Anti-diabetic effects of blue honeyberry on high-fed-diet-induced type II diabetic mouse.Nutrition research and practice · 2019Article
- Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation.Journal of cell communication and signaling · 2018Article
- Immune Abnormalities in Autism Spectrum Disorder-Could They Hold Promise for Causative Treatment?Molecular neurobiology · 2018Review
- Type 1 Diabetes and Its Multi-Factorial Pathogenesis: The Putative Role of NK Cells.International journal of molecular sciences · 2018Review
- Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review.Frontiers in pharmacology · 2017Review
- NK receptors: tools for a polyvalent cell family.Frontiers in immunology · 2014Article
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Authors and funding
2 authors.
Funding
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Abstract
Natural killer (NK) cells are innate immune lymphocytes that function mainly as immune sentinels against viral infection and tumorigenesis. NK cell function is governed by inhibitory and activating signals arising from corresponding receptors. A prominent group of activating NK receptors is the natural cytotoxicity receptors (NCRs), which includes NKp30, NKp44, and NKp46. These receptors bind various diverse ligands of pathogenic, tumor, and even self origin. Type 1 diabetes mellitus (T1D) is a multifactorial autoimmune disease, in which insulin-producing beta (β) cells are ablated by the immune system. This killing of β cells is carried out mainly by T cells, but many other immune cells have been implicated in the pathogenesis of this disease. Importantly, NK cells were shown to be key participants in the initial autoimmune attack. It was shown that all β cells from humans and mice, healthy or sick, express an unknown ligand for the activating NKp46 receptor. In this review, we describe the role played by the NCRs in various pathologies with an emphasis on Type I diabetes.
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