Evidence map›Paper›PMID 24478760›Full record

ReviewFrontiers in endocrinology2014

Central and direct regulation of testicular activity by gonadotropin-inhibitory hormone and its receptor.

Takayoshi Ubuka, You Lee Son, Yasuko Tobari, Misato Narihiro, George E Bentley, Lance J Kriegsfeld, Kazuyoshi Tsutsui

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
11.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Review
  3. Neuropeptide FF indirectly affects testicular morphogenesis and functions in medaka.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Taste Receptors: New Players in Sperm Biology.International journal of molecular sciences · 2019
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Takayoshi UbukaDepartment of Biology, Center for Medical Life Science, Waseda University , Tokyo , Japan.
You Lee SonDepartment of Biology, Center for Medical Life Science, Waseda University , Tokyo , Japan.
Yasuko TobariDepartment of Biology, Center for Medical Life Science, Waseda University , Tokyo , Japan.
Misato NarihiroDepartment of Biology, Center for Medical Life Science, Waseda University , Tokyo , Japan.
George E BentleyDepartment of Integrative Biology, Helen Wills Neuroscience Institute, University of California at Berkeley , Berkeley, CA , USA.
Lance J KriegsfeldDepartment of Psychology, Helen Wills Neuroscience Institute, University of California at Berkeley , Berkeley, CA , USA.
Kazuyoshi TsutsuiDepartment of Biology, Center for Medical Life Science, Waseda University , Tokyo , Japan.
Waseda University · JPUniversity of California, Berkeley · US

Funding

The role of kisspeptin and RFRP-3 in the neuroendocrine control of female reproductionR01HD050470 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRIEGSFELD, LANCE J · 2007 to 2022
$5.0M
NICHD NIH HHS R01 HD050470
6 · The paper itself

Abstract

Gonadotropin-inhibitory hormone (GnIH) was first identified in Japanese quail to be an inhibitor of gonadotropin synthesis and release. GnIH peptides have since been identified in all vertebrates, and all share an LPXRFamide (X = L or Q) motif at their C-termini. The receptor for GnIH is the G protein-coupled receptor 147 (GPR147), which inhibits cAMP signaling. Cell bodies of GnIH neurons are located in the paraventricular nucleus (PVN) in birds and the dorsomedial hypothalamic area (DMH) in most mammals. GnIH neurons in the PVN or DMH project to the median eminence to control anterior pituitary function via GPR147 expressed in gonadotropes. Further, GnIH inhibits gonadotropin-releasing hormone (GnRH)-induced gonadotropin subunit gene transcription by inhibiting the adenylate cyclase/cAMP/PKA-dependent ERK pathway in an immortalized mouse gonadotrope cell line (LβT2 cells). GnIH neurons also project to GnRH neurons that express GPR147 in the preoptic area (POA) in birds and mammals. Accordingly, GnIH can inhibit gonadotropin synthesis and release by decreasing the activity of GnRH neurons as well as by directly inhibiting pituitary gonadotrope activity. GnIH and GPR147 can thus centrally suppress testosterone secretion and spermatogenesis by acting in the hypothalamic-pituitary-gonadal axis. GnIH and GPR147 are also expressed in the testis of birds and mammals, possibly acting in an autocrine/paracrine manner to suppress testosterone secretion and spermatogenesis. GnIH expression is also regulated by melatonin, stress, and social environment in birds and mammals. Accordingly, the GnIH-GPR147 system may play a role in transducing physical and social environmental information to regulate optimal testicular activity in birds and mammals. This review discusses central and direct inhibitory effects of GnIH and GPR147 on testosterone secretion and spermatogenesis in birds and mammals.

Indexed as

gonadotropin-inhibitory hormonegonadotropinsGPR147melatoninsocial environmentspermatogenesisstresstestosterone

Identifiers

PMID24478760
PMCPMC3902780
OpenAlexW2050636051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.