ArticleFrontiers in aging neuroscience2014
Assessing the emergence and reliability of cognitive decline over the life span in Fisher 344 rats using the spatial water maze.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Biological sex and normative cognitive aging across spatial learning, flexibility, and working memory in Fischer 344 rats.Behavioral neuroscience · 2026Article
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- Effects of cannabis smoke and oral Δ9THC on cognition in young adult and aged rats.Psychopharmacology · 2025Article
- Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging.Advances in experimental medicine and biology · 2025Review
- Senolytic treatment alleviates doxorubicin-induced chemobrain.Aging cell · 2024Article
- Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging.Frontiers in aging neuroscience · 2024Article
- Assessing cognitive decline in the aging brain: lessons from rodent and human studies.npj aging · 2023Review
- Article
- Age-related impairments on the touchscreen paired associates learning (PAL) task in male rats.Neurobiology of aging · 2022Article
- Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline.Aging · 2021Article
- Adolescent Binge-Type Ethanol Exposure in Rats Mirrors Age-Related Cognitive Decline by Suppressing Cholinergic Tone and Hippocampal Neurogenesis.Frontiers in behavioral neuroscience · 2021Article
- Apoaequorin differentially modulates fear memory in adult and aged rats.Brain and behavior · 2020Article
- Differential Effect of Repeated Lipopolysaccharide Treatment and Aging on Hippocampal Function and Biomarkers of Hippocampal Senescence.Molecular neurobiology · 2020Article
- Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory.Frontiers in aging neuroscience · 2020Article
- Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.Frontiers in aging neuroscience · 2020Review
- APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts.Journal of neuroinflammation · 2018Article
- Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity.Neurobiology of aging · 2018Article
- Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Transcription Profile of Aging and Cognition-Related Genes in the Medial Prefrontal Cortex.Frontiers in aging neuroscience · 2016Article
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4 authors.
Funding
Abstract
The spatial water maze is routinely used to investigate hippocampal-dependent spatial memory and the biological mechanisms that underlie variability in cognitive decline during aging. The utility of the task for repeated testing in order to examine the trajectory of cognitive decline and to prescreen animals prior to therapeutic interventions maybe limited due to carryover effects of repeated training. The current study examines the role of carryover effects, as well as the reliability of individual differences, in determining age-related impairment on episodic and reference memory versions of the water maze task. Results indicate that impaired acquisition of episodic spatial information emerges in middle-age and the propensity for impairment increases with advancing age. While learning was variable across animals, acquisition deficits for episodic information were reliable across training sessions in middle-age and aged rats. A significant impairment in the 24~h retention of episodic spatial information was observed in aged animals. When animals were trained to the same location (i.e., reference memory), an impairment was limited to the rate of acquisition in aged animals. However, with continued training, all aged animals were able to acquire a reference memory and no age differences were observed in the 24~h retention of a spatial reference memory. Together, the results point to a progressive impairment in episodic spatial memory with advancing age and suggest that tests of episodic spatial memory are reliable and more sensitive than reference memory for detecting cognitive decline.
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