ArticleFrontiers in computational neuroscience2013
Transient and steady-state selection in the striatal microcircuit.
Article in Frontiers in computational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Dose-Dependent Effects of Catecholaminergic Modulation on Interference Control: Role of Baseline GABA and Glx in Cortico-Subcortical Networks.Human brain mapping · 2025Trial
- Dopamine Modulates the Efficiency of Sensory Evidence Accumulation During Perceptual Decision Making.The international journal of neuropsychopharmacology · 2018Trial
- Break-up and recovery of harmony between direct and indirect pathways in the basal ganglia: Huntington's disease and treatment.Cognitive neurodynamics · 2024Article
- Quantifying harmony between direct and indirect pathways in the basal ganglia: healthy and Parkinsonian states.Cognitive neurodynamics · 2024Article
- Effective Regulation of Auditory Processing by Parvalbumin Interneurons in the Tail of the Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Gamma-Aminobutyric Acid and Glutamate Concentrations in the Striatum and Anterior Cingulate Cortex Not Found to Be Associated with Cognitive Flexibility.Brain sciences · 2023Article
- Black-box and surrogate optimization for tuning spiking neural models of striatum plasticity.Frontiers in neuroinformatics · 2022Article
- Making decisions in the dark basement of the brain: A look back at the GPR model of action selection and the basal ganglia.Biological cybernetics · 2021Article
- On the functional role of striatal and anterior cingulate GABA+ in stimulus-response binding.Human brain mapping · 2021Article
- Acute Alcohol Effects on Response Inhibition Depend on Response Automatization, but not on GABA or Glutamate Levels in the ACC and Striatum.Journal of clinical medicine · 2020Article
- Predictive coding and adaptive behavior in patients with genetically determined cerebellar ataxia--A neurophysiology study.NeuroImage. Clinical · 2019Article
- Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175+/- mouse model of Huntington's Disease.PloS one · 2018Article
- Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2.Frontiers in neural circuits · 2018Review
- Striatal Neuropeptides Enhance Selection and Rejection of Sequential Actions.Frontiers in computational neuroscience · 2017Article
- The role of cortical oscillations in a spiking neural network model of the basal ganglia.PloS one · 2017Article
- A perspective on neural and cognitive mechanisms of error commission.Frontiers in behavioral neuroscience · 2015Review
- Decision-making and action selection in insects: inspiration from vertebrate-based theories.Frontiers in behavioral neuroscience · 2015Review
- Basal ganglia: physiological, behavioral, and computational studies.Frontiers in systems neuroscience · 2014Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Although the basal ganglia have been widely studied and implicated in signal processing and action selection, little information is known about the active role the striatal microcircuit plays in action selection in the basal ganglia-thalamo-cortical loops. To address this knowledge gap we use a large scale three dimensional spiking model of the striatum, combined with a rate coded model of the basal ganglia-thalamo-cortical loop, to asses the computational role the striatum plays in action selection. We identify a robust transient phenomena generated by the striatal microcircuit, which temporarily enhances the difference between two competing cortical inputs. We show that this transient is sufficient to modulate decision making in the basal ganglia-thalamo-cortical circuit. We also find that the transient selection originates from a novel adaptation effect in single striatal projection neurons, which is amenable to experimental testing. Finally, we compared transient selection with models implementing classical steady-state selection. We challenged both forms of model to account for recent reports of paradoxically enhanced response selection in Huntington's disease patients. We found that steady-state selection was uniformly impaired under all simulated Huntington's conditions, but transient selection was enhanced given a sufficient Huntington's-like increase in NMDA receptor sensitivity. Thus our models provide an intriguing hypothesis for the mechanisms underlying the paradoxical cognitive improvements in manifest Huntington's patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.