ReviewFrontiers in behavioral neuroscience2013
Identification and optogenetic manipulation of memory engrams in the hippocampus.
Review in Frontiers in behavioral neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Restoring access to long-term social recognition memories disrupted by sleep deprivation.Science advances · 2026Article
- Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long-Term Active Place Avoidance Memory and "Shadow" Proteins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cocaine-context memories are transcriptionally encoded in nucleus accumbens Arc ensembles.Nature communications · 2025Article
- Age-related differences in trust decisions: when memory fails and appearances prevail.Social cognitive and affective neuroscience · 2025Article
- Distinct spatial distribution of potentiated dendritic spines in encoding- and recall-activated hippocampal neurons.Frontiers in molecular neuroscience · 2025Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- Arthropod promoters for genetic control of disease vectors.Trends in parasitology · 2024Review
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus.Frontiers in molecular neuroscience · 2024Review
- Early deficits in dentate circuit and behavioral pattern separation after concussive brain injury.Experimental neurology · 2023Article
- Empirical mode decomposition of local field potential data from optogenetic experiments.Frontiers in computational neuroscience · 2023Article
- Conceptualizing traumatic stress and the structure of posttraumatic psychopathology through the lenses of RDoC and HiTOP.Clinical psychology review · 2022Review
- Neurons as will and representation.Nature reviews. Neuroscience · 2022Review
- Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia.Frontiers in integrative neuroscience · 2022Article
- Using a Foreign Language Changes Medical Judgments of Preventative Care.Brain sciences · 2021Article
- Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).The European journal of neuroscience · 2021Review
- fMRI evidence reveals emotional biases in bilingual decision making.Brain structure & function · 2021Article
- Drug-activated cells: From immediate early genes to neuronal ensembles in addiction.Advances in pharmacology (San Diego, Calif.) · 2021Review
- Article
- Modulation of Human Memory by Deep Brain Stimulation of the Entorhinal-Hippocampal Circuitry.Neuron · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
With the accumulation of our knowledge about how memories are formed, consolidated, retrieved, and updated, neuroscience is now reaching a point where discrete memories can be identified and manipulated at rapid timescales. Here, we start with historical studies that lead to the modern memory engram theory. Then, we will review recent advances in memory engram research that combine transgenic and optogenetic approaches to reveal the underlying neuronal substrates sufficient for activating mnemonic processes. We will focus on three concepts: (1) isolating memory engrams at the level of single cells to tag them for subsequent manipulation; (2) testing the sufficiency of these engrams for memory recall by artificially activating them; and (3) presenting new stimuli during the artificial activation of these engrams to induce an association between the two to form a false memory. We propose that hippocampal cells that show activity-dependent changes during learning construct a cellular basis for contextual memory engrams.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.