ArticleFrontiers in cellular neuroscience2014
GABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 40 citations in OpenAlex.
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- Morphological evidence for neuronal connections between the olfactory neurogenic region and the striatum in adult rats.Frontiers in neural circuits · 2025Article
- Beyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma.Frontiers in cell and developmental biology · 2025Review
- Regulation of neural stem cells by innervating neurons.Journal of neurochemistry · 2025Review
- Gene Expression of GABABrain sciences · 2024Article
- Adult neurogenesis: a real hope or a delusion?Neural regeneration research · 2024Review
- Culture Protocol and Transcriptomic Analysis of Murine SVZ NPCs and OPCs.Stem cell reviews and reports · 2023Article
- GABAJournal, genetic engineering & biotechnology · 2021Review
- Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain.Development (Cambridge, England) · 2019Review
- Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke.Neural plasticity · 2019Review
- Neuronal Activity-Dependent Control of Postnatal Neurogenesis and Gliogenesis.Annual review of neuroscience · 2018Review
- Optical inhibition of striatal neurons promotes focal neurogenesis and neurobehavioral recovery in mice after middle cerebral artery occlusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice.Neurobiology of disease · 2017Article
- Neural Stem Cell Plasticity: Advantages in Therapy for the Injured Central Nervous System.Frontiers in cell and developmental biology · 2017Review
- The effects of repetitive transcranial magnetic stimulation on proliferation and differentiation of neural stem cells.Anatomy & cell biology · 2015Article
- Comparison of immunoreactivities of calbindin-D28k, calretinin and parvalbumin in the striatum between young, adult and aged mice, rats and gerbils.Neurochemical research · 2015Article
- Exosomes as Novel Regulators of Adult Neurogenic Niches.Frontiers in cellular neuroscience · 2015Review
- Axons take a dive: Specialized contacts of serotonergic axons with cells in the walls of the lateral ventricles in mice and humans.Neurogenesis (Austin, Tex.) · 2014Article
- Regulation of adult neurogenesis by GABAergic transmission: signaling beyond GABAA-receptors.Frontiers in cellular neuroscience · 2014Review
- Cholinergic Circuit Control of Postnatal Neurogenesis.Neurogenesis (Austin, Tex.)Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
GABA regulates the behavior of neuroblasts and neural progenitor cells in the postnatal neurogenic subventricular zone (SVZ) through GABAA receptor (GABAAR)-mediated calcium increases. However, the source of GABA necessary for sufficient GABAAR-mediated depolarization and calcium increase has remained speculative. Here, we explored whether GABAergic striatal neurons functionally connect with SVZ cells. Using patch clamp recordings or single cell electroporation, striatal neurons along the SVZ were filled with a fluorescent dye revealing that they send both dendrites and axons into the SVZ. About 93% of the recorded neurons were medium spiny or aspiny GABAergic neurons and each neuron sent 3-4 processes into the SVZ covering ~56 μm. Using calcium imaging, we found that depolarization of striatal neurons led to increased calcium activity in SVZ cells that were mediated by GABAAR activation. Collectively, these findings undercover a novel mode of signaling in the SVZ providing a mechanism of brain activity-mediated regulation of postnatal neurogenesis through GABAergic striatal activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.